Lead AI Scientist

Quotient Therapeutics develops breakthrough medicines informed by natural somatic genetic diversity present in patients. Through our work in somatic genomics, we are forging a new status quo for biopharma research and development across a broad pipeline of internal and partnered programs. We are a privately held, early-stage company and are an equal opportunity employer.

Quotient was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS).

Position Summary:

We are seeking a lead AI scientist to invent and productionize computational capabilities that power target identification, validation, and drug development. The candidate is experienced and excited to operate in a deeply collaborative way with peers in data infrastructure, assay development, biology validation, and drug discovery. They bring enthusiasm, intellectual curiosity, scientific rigor, and a deep-rooted desire to innovate. The candidate will have Director level seniority and report to the head of assay development and data science. This role is based in the vicinity of Cambridge UK and hybrid work arrangements will be considered, but all applicants will require permission to work in UK.

Key Responsibilities:

• Collaborate with key stakeholders to set the technical strategy and roadmap for AI across the platform and drug discovery, then define execution plans and deliver against them.
• Lead, mentor, and grow the AI/ML team, fostering a focus on collaboration and delivery, while maintaining standards for quality and reproducibility.
• Partner with Data Infrastructure to optimize data schemas, metadata, versioning, and access controls for ML training and inference.
• Develop and deploy methods leveraging next-generation sequencing for target discovery and validation.
• Develop and deploy methods leveraging imaging AI of histology images, such as segmentation/detection/classification, weak/self-supervised learning, and rigorous model evaluation tied to biological goals.
• Develop and deploy methods to accelerate the validation of targets using standardised assays and accelerate drug development.
• Communicate results and decisions clearly to technical and non-technical stakeholders.

Requirements:

• PhD or equivalent experience in genomics, computational biology, computer science, or similar discipline is required.
• 3–7 years of industry experience delivering AI/ML systems for target discovery and/or drug development, with end-to-end ownership from method development to production.
• Strong leadership and collaboration skills in a matrix environment with a low-ego, high-ownership working style.
• High proficiency in Python and modern ML tooling, cloud computing environments (e.g., AWS), as well as solid software engineering habits (testing, CI/CD, containers, etc.).
• Priority domain experience:
  • Genomics/NGS: development of methods to leveraging sequencing technologies.
  • Imaging AI: microscopy/histology, WSI pipelines, dataset curation/labeling strategies, scalable training and evaluation.
  • Validation and drug discovery: development or application of AI tools to target validation using in-vitro models and/or drug discovery in any modality.
• A high degree of energy, accuracy and attention to detail, and a passion for creating transformative medicines for patients with serious diseases.

Recruitment & Staffing Agencies

Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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