VAC_64_2024_POSTDOCTORAL RESEARCHER (computational background)_3D Chromatin Organization

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VAC_64_2024_POSTDOCTORAL RESEARCHER (computational background)_3D Chromatin Organization

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Job description

Offer DescriptionThe Josep Carreras Leukaemia Research Institute (IJC) is a non-profit research institute based in Barcelona and dedicated to advancing our understanding about leukaemia and related disorders, in partnership with the University of Barcelona and University Autònoma of Barcelona. The IJC has laboratories in three clinical campuses: i) Clinic Hospital, ii) Sant Pau Hospital and iii) Germans Trias i Pujol Hospital. IJC serves as a collaborative hub for basic investigators and physicians to work together on fundamental biological and clinical aspects of leukaemia. The IJC offers an excellent work environment built around a multi-disciplinary fusion of ideas and state-of-the-art facilities.Research DescriptionWe are currently seeking for an enthusiastic Postdoctoral Researcher to be part of the multidisciplinary research team of the research line “Multi-omics approach to improve therapeutic management of acute lymphoblastic leukemia” funded by “AECC” and led by Biola M. Javierre (IJC).Relapse is a major challenge in acute lymphoblastic leukemia (ALL) since 50% of the adult patients relapse and 90% of those do not overcome the disease. While the causes of relapse are not completely understood, there is evidence suggesting that noncoding mutations might play important roles in disease persistence. In this project we will use a multi-omics approach to decipher the molecular basis of ALL relapse and mortality. In summary, this interdisciplinary project will provide unprecedented insights into our understanding of ALL and relapse. Besides, it will allow to predict which patients will unexpectedly relapse and propose new therapeutic strategies to ultimately avoid relapse and mortality.Javierre TeamWe are a group of passionate scientists with an insatiable thirst for learning about the spatio-temporal organization of the DNA. Our group combines cutting-edge experimental and bioinformatics approaches to understand the specific 3D chromatin organization of haematopoietic cells and its alteration in blood cancers. Our long-term goal is to keep taking steps forward in the fight against cancer. We will be unstoppable until we cure it. To do so, we have established a close collaboration with the group lead by Alfonso Valencia, Barcelona Supercomputing Center ( ).The main research goals of our lab are: * Defining the cell type-specific 3D chromatin organization in human haematopoietic cells.

• Identifying the altered DNA topology in blood cancer
• Study non-coding mutations to prioritize new candidate genes and pathways related to blood cancer-based

For more information, please contract 3D Chromatin Organization Research Group’s webpage ( ) and the IJC web page ( ).Main Responsibilities

• She/he will be part of the multidisciplinary research team focused on the research line “Multi-omics approach to improve therapeutic management of acute lymphoblastic leukemia” funded by “AECC” and led by Biola M. Javierre (IJC).
• Specifically, she/he will lead the computational analysis of the project and coordinate data management.
• She/he will supervise students and support grant applications.

Where to apply WebsiteRequirementsResearch Field Medical sciences » Cancer research Education Level PhD or equivalentSkills/Qualifications

• A high level of motivation and interest.
• PhD degree in bioinformatics, computational biology or similar.
• Expertise, at least, in one of the following areas: genome organization, gene regulation, epigenenomics, single cell omics, GWAS, WGS.
• Ability to handle varying workloads and aptitude for teamwork.
• High level of collaborative and communicative skills.
• Good level of English speaking and writing skills (required). Spanish (helpful).

Languages ENGLISHAdditional InformationBenefits

• Three years full-funded position. Salary will be adjusted according to the experience of the candidate.
• Contract funded by Fundación Asociación Española Contra el Cáncer (FAECC), under call Lab AECC 2021, ref: LABAE21981JAVI.
• An exciting and innovative research project funded by the prestigious LaB AECC
• Working in the mixed basic and clinical research environment of the Josep Carreras Leukaemia Research Institute.
• Incorporation in a multinational and highly collaborative team.
• The stimulating environment of the Barcelona metropolitan area.
• We will provide support and training to prepare competitive fellowship applications (e.g., Marie Curie, EMBO, FEBS, HFSP among others)

Work Location(s)Number of offers available 1 Company/Institute Institut de Recerca contra la Leucemia Josep Carreras Country Spain State/Province Barcelona City Badalona Postal Code 08916 Street Carretera de Can Ruti, Camí de les Escoles, s/nContact State/ProvinceBarcelona CityBadalona WebsiteStreetCarretera de Can Ruti, Camí de les Escoles, s/n Postal Code08916STATUS: EXPIREDShare this page

Expected salary

Location

Badalona, Barcelona

Job date

Fri, 23 Aug 2024 05:08:07 GMT

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