Job title:
UJA MSCA-Postdoctoral Fellowship Hosting Offer (LIF – Life Sciences)
Company:
Job description
Universidad de Jaén is a public higher education institution based in Andalucía (Spain) that was created in 1993 and which has received the distinction of Campus of International Excellence in the fields of Agrifood (CEIA3) and Climate Change (CamBio), plus it also leads the Andalusian CEI project on historical heritage PatrimoniUN10. Besides, the UJA highly ranks for its contribution to the Sustainable Development Goals according to THE – Times Higher Education (World University Rankings). UJA has five faculties (Social and Legal Sciences; Humanities and Education Sciences; Health Sciences; Experimental Sciences and Social Work) and two higher polytechnic schools for engineering (Linares and Jaén) as well as an associated center (SAFA Professional School in Úbeda). In turn, these centers are organized into 35 departments, plus six specialized centers at UJA (CAAI, INUO, IISTA, DaSCI, CEACTEMA, CEATIC) strongly contribute to the university’s outstanding R&I performance. Universidad de Jaén is also renowned for its well-established links with industry and generation of spin-offs, plus for its internationalization strategy, As an example, UJA is a member of GUNi, EUA, Food4LifeSpain, BIC Consortium, S3 Partnership on Sustainable Buildings, AgrotechDIH or I4-GREEN, plus it has also contributed to EIP on Raw Materials and EIP-AGRI.Supervision profilewould be willing to receive expressions of interest from candidates with a competitive CV (also including high quality and impact publications, international mobility and relevant transferable skills) within the framework of the . Support to prospecte applicants will be provided by the UJA R&I International Projects Office (OFIPI).Requested expertise (and training provided)The main aim of our laboratory is to understand the molecular mechanisms driving cardiovascular development. During recent years we focused on dissecting the role of the homeobox transcription factor Pitx2 during cardiogenesis by generating atrial and ventricular chamber conditional mouse mutants. While cardiac development was not compromised, atrial-chamber specific conditional mutants displayed impaired electrophysiological parameters, reminiscent of atrial fibrillation. Subsequently we discerned that Pitx2
Wnt
microRNAs signaling pathway is key to maintain electrophysiological homeostasis in the developing and adult heart. Over the last years we have centered our attention to dissect the role of non-coding RNAs during cardiogenesis as well as in cardiac pathologies such as atrial fibrillation and dilated cardiomyopathy, including therein microRNAs and lncRNAs. We have identified key microRNAs and lncRNAs that contribute to these pathologies. We are currently generating genetically engineered mouse models to dissect their role in vivo. A second research line in our laboratory is directed to discern the functional role of microRNAs and lncRNAs during epicardial development. Bulk RNA seq analyses provided us with the bases to investigate the role of distinct differentially expressed transcription factors, microRNAs and lncRNAs during epicardial formation as well as in physiopathological processes in which the epicardium plays a key role, such as cardiac regeneration. In this context, we have generated in our laboratory a mouse cryoinjured model to dissect their role during cardiac regeneration. Additionally, we are also dissecting the role of Pitx2 in the epicardial development by generating tissue-specific conditional mouse models. In summary, our main goal is to dissect the role of distinct transcription factors, microRNAs and lncRNAs during heart formation, using different cellular, molecular biology and genetic tools in mice.Share this page
Expected salary
Location
Jaén
Job date
Thu, 12 Dec 2024 05:56:24 GMT
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