The Institute of Evolutionary Biology seeks a: Postdoctoral researcher

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The Institute of Evolutionary Biology seeks a: Postdoctoral researcher

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Job description

Offer DescriptionOFFER DESCRIPTION:3-year fully-funded Postdoc position within the ERC Starting Grant Mut-ScalesProject overviewHow do long-lived species maintain lower mutation rates and minimize the impacts of DNA damage over time? This project aims to uncover the molecular mechanisms that have evolved to protect cells from DNA damage and reduce mutational burden in species with diverse life histories.Using primary fibroblast cell lines from diverse mammalian species, we aim to systematically compare their cellular responses to controlled mutagen exposure. By measuring changes in mutation rates, gene expression, chromatin accessibility, and cell viability, the project seeks to:

• Identify core pathways that mitigate DNA damage and reduce mutation accumulation.
• Reveal how evolutionary adaptations enable longer-lived species to maintain genome integrity over time.
• Provide new insights into the molecular underpinnings of cancer resistance and longevity.

This project will be supported by a lab technician to run the experiments. It will combine experimental assays with cutting-edge genomics to deepen our understanding of the DNA damage response in mammals, with implications for evolutionary biology, aging, and disease.About theAs individuals age, mutations accumulate in their cells, playing a pivotal role in evolution, aging, and disease. Despite their importance, much remains unknown about how mutations originate or why some cells accumulate more mutations than others. Our lab aims to elucidate the fundamental mechanisms behind mutation formation and investigates the evolutionary forces that shape mutation rates across different cell types and species. We are part of the , a collaborative initiative by the IBE, UPF, and CRG.

About the Institute
The (IBE) is a joint Institute of the Spanish National Research Council (CSIC) and Pompeu Fabra University (UPF), located in Barcelona. IBE’s research is focused on the processes and mechanisms that generate biodiversity and on understanding the genetic basis of evolution. The IBE is part of the (PRBB), a stimulating international research environment with state-of-the-art facilities.Where to apply WebsiteRequirementsResearch Field Biological sciences » Biology Education Level PhD or equivalentSkills/QualificationsExperience with cell culture, sequencing, and standard molecular biology techniques will be highly valued. Familiarity with data analysis pipelines for omics sequencing data (bash, HPCs, and R/Python). Strong organizational and communication skills.Languages ENGLISH Level ExcellentInternal Application form(s) neededPostdoc_ERC_2024.pdfEnglish(443.23 KB – PDF)Additional InformationWork Location(s)Number of offers available 1 Company/Institute Institute of Evolutionary Biology (IBE: CSIC-UPF) Country Spain City Barcelona GeofieldContact CityBarcelona WebsiteStreetPasseig maritim de la Barceloneta 37-49 Postal Code08003 E-Mailmarc.demanuel@ibe.upf-csic.esSTATUS: EXPIREDShare this page

Expected salary

Location

Barcelona

Job date

Wed, 27 Nov 2024 07:20:33 GMT

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