Senior Laboratory Research Scientist – Human Models

Job title:

Senior Laboratory Research Scientist – Human Models

Company:

Francis Crick Institute

Job description

Salary for this Role:£39,950 – £45,275, subject to skills and experience, with benefits.Job Title: Senior Laboratory Research Scientist – Human ModelsReports to: Daria ParuzinaClosing Date: 03/Jan/2025 23.59 GMTJob Description:Senior Laboratory Research Scientist – Human Models CoreReports to: Head of Lab Operations (HBF)This is a full-time, permanent position on Crick terms and conditions of employment.OverviewThe Human Models Core (HMC) is an integral part of the Human Biology Facility. HMC comprises of scientific and technical staff from the Francis Crick Institute who provide a service and support to all researchers. With close links to the Human Biology Governance Team and external partners the HMC provide a comprehensive range of services and support for human model’s research. Within the HMC there are 4 distinct core units: viral vectors, human embryo and stem cell unit (HESCU), human cell engineering and primary models.The area of pluripotent stem cell research is a dynamic field with a broad scope of applications due to the ability of the cells to differentiate down lineages representative of all three germ layers. Apart from the potential clinical application of human pluripotent stem cells (PSC) in the field of cell therapies, the use of these cells is well established in area of assay development, modelling of developmental pathways and disease modelling. The utilisation of these applications coupled with the use of gene editing tools such as CRISPR makes this type of biological system ideal to study the effects of gene knockout or gene modification.Project summaryHESCU is involved in developing key models for human disease by reprogramming somatic cells into PSC lines and assist with downstream applications like gene editing or differentiation.HESCU provides and maintains a well-equipped laboratory space and as a communal lab space, facilitates interaction between the groups working with human models, pluripotent stem cells and gene editing. The Lab aims at fostering collaborations, knowledge hub and the sharing of protocols between the scientific groups who use the facility. We currently work with users to provide support and promote best practice, in the areas of growing pluripotent stem cells, differentiation, characterisation, banking and method development.We are looking for a motivated, collaborative, scientist to work with HESCU /HMC staff, other STP scientist and the users to standardise reprogramming, QC and bank of PSC lines.Key responsibilitiesThese include but are not limited to:Reprogramming somatic cells to iPSCs.Generation of iPSC derived organoids and other modelsWorking and collaborating with scientist to develop scientific projectsProvision of pluripotent stem cell culture suite, PSC QC and technical support to scientific groups within the Francis Crick Institute.Teaching and training scientists in the best practice skillsets necessary to grow, characterise, differentiate and bank human PSC.Support PSC genome editing unit, where neededProvision of support for the day-to-day running of the facility including but not limited to housekeeping, equipment maintenance.

Maintenance of databases and records for the unitMonitoring and communication status of projectsBudget managementKey experience and competenciesThe post holder should embody and demonstrate our core Crick values: bold, open, and collegial, in addition to the following:EssentialQualifications, experience and competencies:PhD (or equivalent) in cell biology, stem cells, genetics or a relevant scientific disciplineSubstantial experience in reprogramming cells to pluripotencyExtensive experience with quality control of PSC and related experience in a range of molecular biology techniques flow cytometryExperience in human organoid culture techniquesStrong communication skills to audiences of varied expertiseProven track record of laboratory managerial and leadership skillsExcellent organizational and time management skillsExperience in facilitating collaborationsAbility to teach and demonstrate techniques to other scientific staffExcellent organisational skills and record keeping with attention to detailHighly self-motivated with a pro-active approachProven ability to work both collaboratively and independentlyProven ability to drive projects and proficient in project managementDesirableQualifications, experience and competencies:Excellent inter-personal skills and a willingness to learn new skillsWorks well in a team and independentlyA good working knowledge of Microsoft Office and internet skillsAbility to work with diverse databasesAwareness of the compliance of stem cells and other human materialProven track record of leading independent projects and/or technology developmentAbility to develop new scientific research methods and to contribute to research strategyPlease note, the advert may be taken down before the closing date if a suitable candidate is found, therefore we would suggest that you apply for this role as soon as possible.Find out what benefits the Crick has to offer:For more information on our great pay and benefits package please click here:Equality, Diversity & Inclusion:We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.Read more on our website:

Expected salary

£39950 – 45275 per year

Location

London

Job date

Thu, 28 Nov 2024 03:27:59 GMT

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