Role of Bitter Taste Receptors in inflammatory intestinal diseases: possible therapeutic targets

Job title:

Role of Bitter Taste Receptors in inflammatory intestinal diseases: possible therapeutic targets

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Job description

Offer DescriptionBitter taste receptors (TAS2R) have been found expressed primarily in the oral cavity and represent the second largest group of chemosensory G-protein coupled receptors. However, in the last decade, the expression of several TAS2Rs has been found in stomach and duodenum, followed by several evidence demonstrating their expression on different cell types in the gut epithelium, suggesting a role of bitter ligands in the gut both in hormonal secretion and in the protective immunity. The role of bitter signaling in the field of gut disorders has never been investigated and this project aims to study the role of several subtype of hTAS2R (e.g. 38 and 46) studying their involvement in peristalsis and in the inflammatory process in inflammatory bowel diseases (IBD), both heavily involved in the pathogenesis of IBD using in vitro and in vivo models.Where to apply WebsiteRequirementsAdditional InformationEligibility criteriaThe public call with detailed attendance and selection rules (Art 4 and 6) can be found at:
Main requirements are:1) degree (with a course duration of not less than 4 years, as referred to in the pre-existing academic regulations pursuant to D.M. n. 509/1999) or post-graduate degrees (pursuant to D.M. n. 509/1999 and to n. 270/2004) awarded by Italian or foreign Universities recognized as equivalent – for the purposes of establishing the equivalence, candidates must provide the necessary documentation to enable the evaluating board to proceed with the qualification assessment; 2) scientific or professional curriculum suitable for conducting the research activity; 3) Ph.D. title (Art 2- par. 1).Additional specific qualifications that can be assessed (to be indicated in art. 6):
experience in cell models, experience in biochemical techniques and molecular biology. Experience in bioinformatics analysis and course for animal manipulation are welcome
Knowledge of the English language
Documented laboratory and research activity (CV with list of publications and presentations at conferences, poster)
Reference letter from the supervisor of the degree thesis and the PhD thesis, if possible

Eligible destination country/ies for fellows:

• AFRICA
• EUROPE
• OCEANIA
• NORTH AMERICA
• SOUTH AMERICA
• ASIA
• OTHER

Eligibility of fellows: country/ies of residence:

• AFRICA
• EUROPE
• OCEANIA
• NORTH AMERICA
• SOUTH AMERICA
• ASIA
• OTHER

Eligibility of fellows: nationality/ies:

• AFRICA
• EUROPE
• OCEANIA
• NORTH AMERICA
• SOUTH AMERICA
• ASIA
• OTHER

Selection processThe application for admission to the selection procedure (dated and signed),the documents and publications considered useful for the evaluation must be submitted, under penalty of exclusion, electronically, by visiting the following web page:
by choosing the “Assegni di ricerca”; item and selecting the Competition Notice you have chosen. In order to register with the system, you must have an email address. Following the guidelines published in the procedure, the applicant must enter all the information required for the application, enclosing all documents in electronic .PDF format. The selection of candidates is carriedout on the basis of qualifications, project and interview, supplemented by a test of knowledge of the foreign language (see art. 6 – paragraph 1).Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Università di Pavia Country Italy GeofieldContact CityPavia WebsiteSTATUS: EXPIREDShare this page

Expected salary

Location

Pavia

Job date

Fri, 30 Aug 2024 05:08:22 GMT

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