Researcher (role in the project: Senior postdoctoral researcher)
Offer DescriptionRecruitment for the project “RNA and Cell Biology Platform for Research and Innovation in Medicine (RACE-PRIME)” (grant agreement no. FENG.02.01-IP.05-T003/23) implemented within the framework of the International Research Agendas funded by the European Funds for Smart Economy programme, for the position Researcher (role in the project: Senior postdoctoral researcher) to carry out research work in the cell biology area under the direction of Prof. Marta Miączyńska, head of the Laboratory of Cell Biology at the International Institute of Molecular and Cell Biology in Warsaw ( ), in collaboration with Prof. Matthias Bochtler (Laboratory of Structural Biology).The aim of RACE-PRIME is to establish IIMCB as a world-class Center of Excellence in RNA and Cell Biology. The goal of RACE-PRIME is to translate basic research findings, e.g., for developing new therapies, diagnostic methods, discovering new therapeutic targets, or identifying molecules with desired properties to be developed into drugs.Description of the project area: KMT2/MLL proteins meditate positive epigenetic memory, by keeping H3K4 tri- and mono-methylation at promoters and enhancers. Germ-line loss of the enhancer directed KMT2D causes a developmental disorder, Kabuki syndrome. Somatic loss of KMT2C and KMT2D is a common occurrence in a broad spectrum of cancers, presumably because functional plasticity favors malignancy.Where to apply E-mailrecruitment@iimcb.gov.plRequirementsResearch Field Biological sciences » Biology Education Level PhD or equivalentResearch Field Chemistry » Biochemistry Education Level PhD or equivalentSkills/QualificationsJob description: The successful candidate will work on KMT2/MLL proteins and their role in positive epigenetic memory. The candidate will participate in (a) tests of a little-studied chromatin mark as the possible anchor for KMT2 proteins, (b) test developmental consequences of a loss of chromatin reader function of KMT2s in WT and mutant embryoid bodies using single cell transcriptomics, and (c) participate in a planned collaboration with the Canadian Structural Biology consortium on a small molecule screen for compounds that stabilize positive epigenetic memory for KMT2 proteins that have fold-destabilizing loss-of-function mutations.Specific RequirementsRequirements: * PhD in biological sciences or related field.
Languages ENGLISH Level GoodResearch Field Biological sciences » BiologyChemistry » Biochemistry Years of Research Experience 4 – 10
Additional InformationBenefitsWe offer: * Full-time employment contract, initially for a period of 6 months with the possibility of extension.Eligibility criteriaSelection criteria: * Education and other formal credentials.
Selection processCandidates will be selected through an open competition, in accordance with the principles set out in the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers, which are part of the HR Excellence in Research strategy.Additional commentsHow to apply: * Please send your applications to the email address:
.The competition may be extended until a candidate meeting all requirements is found. Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute International Institute of Molecular and Cell Biology in Warsaw Country Poland City Warsaw Postal Code 02-109 Street ks. Trojdena 2 GeofieldContact CityWarsaw WebsiteStreet4, Ks. Trojdena Postal Code02-109 E-Mailafaliszewska@iimcb.gov.plSTATUS: EXPIREDShare this page
Warszawa, mazowieckie
Thu, 15 Aug 2024 06:17:03 GMT
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