Research Fellow

Job title:

Research Fellow

Company:

University College London

Job description

About usThe RNA Regulation Laboratory, headed by Prof Andres Ramos is a highly dynamic research environment that applies a multi-disciplinary approach to address key questions in RNA Biology and neuronal regulation. The laboratory is part of the Biosciences Division, a centre of research excellence and one of the largest Divisions within UCL. Research activities in the Division and the linked Institute of Structural and Molecular Biology are underpinned by state-of the-art research facilities hosting and developing methodologies, including cell biology, optical microscopy, bioinformatics and ion mobility mass spectrometry laboratories and well as for X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, single molecules methods. The post-holder will work also take advantage of the microscopy facilities at the UCL LCMB and the Francis Crick Institute, while working on developing neurons in the group of Professor Rickie Patani. The Biosciences Division coordinates a range of undergraduate and master programmes, and host a large number of postgraduate research students funded by MRC, BBSRC, EPSRC and many others. Symposia, retreats and seminar series are an important part of the experience of our community.The Ramos lab promotes independent, creative, thinking, and projects are often in collaboration. The project we propose is an exciting opportunity to explore the role that RNA regulation plays in neuronal development integrating microscopy and transcriptome-wide analysis, with in cell interactome data and structural data on specific target sites. The project is a close collaboration with the group of Rickie Patani at the Francis Crick Institute and the UCL Institute of Neurology, and the post-holder will be work across the two laboratories.About the roleThe research we propose will focus on understanding the molecular basis of local mRNA translation in neuronal development. Important questions include, but are not limited to, how the proteins recognise large networks of functionally related mRNAs targets, how individual regulatory events are integrated to yield complex morphological changes and how the system is tuned by protein and RNA modifications, during development and in response to signalling. The role holder will be expected to pursue original, multi-disciplinary research. The project entails using single molecule microscopy, performing transcriptome and proteome-wide analyses and exploring, in the cell, the molecular component of specific interactions. Also, it features the use of AI-based methods of image analysis to integrate morphological information on developing neurons. The work is in close collaboration with the group of Professor Rickie Patani, where the post holder will perform the neuronal work, but also with experts in bioinformatics and in the required state-of-the-art cell and molecular biology methods. Notably, the post holder will work in close collaboration with a structural biologist and a technician who are also funded by the grant and will be an active member of the Ramos lab.This is an open-ended contract for 30 months from the time of appointment, in the first instance.

Research Fellows – ‘Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Grade 6B (salary £34,502 – £36,348 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD Thesis.’This appointment is subject to UCL Terms and Conditions of Service for Research and Professional Services Staff. Please visit for more information.A job description and person specification can be accessed at the bottom of this page.If you have any queries about the role, please contact Andres Ramos at a.ramos@ucl.ac.ukIf you need reasonable adjustments or a more accessible format to apply for this job online or have any queries about the application process, please contact Biosciences staffing at biosciences.staffing@ucl.ac.uk.About youYou must have a PhD in cell and molecular biology, and some knowledge of bioinformatic analysis. Experience in neurobiology and microscopy methods is also important. You will be expected to work as part of a tightly integrated team to produce original contributions to the mechanistic understanding of the role of RNA regulators in neuronal development. Your studies will focus on the understanding of the IGFBP1/IMP1 system, in the first instance. In addition to developing and conducting the research, you will contribute expertise to the overall research effort in the Ramos group. You will also communicate results as scientific papers in leading journals, and as scientific presentations at national and international conferencesWhat we offerAs well as the exciting opportunities this role presents, we also offer some great benefits some of which are below:

• 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
• Additional 5 days’ annual leave purchase scheme
• Defined benefit career average revalued earnings pension scheme (CARE)
• Cycle to work scheme and season ticket loan
• Relocation scheme for certain posts
• On-Site nursery
• On-site gym
• Enhanced maternity, paternity and adoption pay
• Employee assistance programme: Staff Support Service
• Discounted medical insurance

Visit to find out more.Our commitment to Equality, Diversity and InclusionAs London’s Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world’s talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL’s workforce.These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.Available documents

Expected salary

£34502 – 36348 per year

Location

North West London

Job date

Wed, 02 Oct 2024 07:18:50 GMT

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