Predoctoral researcher R1
Offer DescriptionNucleic acid-based therapies demonstrated their early success during the Covid-19 pandemic in 2020. Nucleic acids are a valuable cargo that needs to be delivered, ideally, to a specific tissue or organ within the human body. However, there are several challenges to achieve this effectively, and the use of nanocarriers is necessary.
To work on these exciting challenges and receive interdisciplinary training in this area, we will be hiring PhD candidates with a background in chemistry, biology, physics, genetics, and material science.At CIPF, 2 positions are being offered for the development of 2 PhD theses:DC12
The Vicent Group recently identified polypeptide-based vectors targeting mitochondria. In this PhD thesis, we will continue this research line, focusing on the design of bioresponsive, polypeptide-based polyplexes capable of targeting mitochondria and releasing selected cargoes through specific stimuli, such as reactive oxygen species (ROS) or other endogenous triggers. We will develop hybrid polypeptide-polypeptoid copolymers incorporating a polyproline moiety. These proline-rich moieties will be linked to the polyplexes, and their safety and transfection efficiency will be explored in cancer models.Scientific Plan and Expected Results:
Throughout this project, the PhD student will be trained in polymer synthesis, bioconjugation techniques, and comprehensive physicochemical characterization, with a focus on bio-nano interfaces and biological evaluation in relevant preclinical models. The project will also include secondments at the University of Bordeaux and the Max Planck Institute for Biophysics.
DC14 Valencia
Sat, 09 Nov 2024 06:42:05 GMT
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