Predoctoral Researcher (Cardiovascular Diseases Research Group)
VHIR
Vall d’Hebron Research Institute (VHIR) offers a position for a Predoctoral researcher within the Laboratory of the Cardiovascular Diseases Research Group to participate in the project “Inhibition of mitochondrial sodium/calcium exchanger, NCLX, as a therapeutic strategy to reduce myocardial ischemia-reperfusion injury during myocardial infarction”, recently funded by Instituto de Salud Carlos III, from Ministerio de Ciencia, Innovación y Universidades (PI23/00260).Education and qualifications:Required:
Desired:
Experience and knowledge:
Main responsibilities and duties:
Labour conditions:
o Background: A key role for the mitochondrial sodium/calcium exchanger, NCLX, in reactive oxygen species (ROS) production during ischemia has been recently unveiled in endothelial and neuronal cells. Preliminary results show that NCLX inhibition can also abolish ROS production during reperfusion and reduces infarction in a mouse model of stroke. As ischemia-reperfusion (IR) injury during acute myocardial infarction is driven by ROS production and oxidative damage, we want to address whether the same mechanism operates in cardiomyocytes, and the therapeutic potential of NCLX inhibition.
o Objectives: (1) To characterize the role of NCLX in ROS production during IR in cardiomyocytes; (2) to evaluate if the application of novel NCLX inhibitors would constitute a promising therapeutic approach to reduce IR injury.o Methods: We will perform a detailed molecular study (superoxide production, cell viability, mitochondrial pH and oxygen consumption) of the effects of mitochondrial sodium-calcium exchange during IR, to understand the molecular pathways leading to ROS production. We will use isolated hearts, in vivo rodent and pig models of myocardial infarction, and cardiomyocytes isolated from human atrial samples to test the usefulness of novel NCLX inhibitors to attenuate IR injury. We expect that inhibition of NCLX may reduce myocardial infarct size by attenuating mitochondrial ROS production.What can we offer? Deadline to apply: 31-12-2024
VHIR embraces Equality and Diversity. As reflected in our values we work toward ensuring inclusion and equal opportunity in recruitment, hiring, training, and management for all staff within the organization, regardless of gender, civil status, family status, sexual orientation, gender identity and expression, religion, age, functional diversity or ethnicity.
Barcelona
Wed, 09 Oct 2024 01:35:43 GMT
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