POSTDOCTORAL RESEARCHER

Job title:

POSTDOCTORAL RESEARCHER

Company:

Job description

Offer DescriptionThe development of immune checkpoint inhibitors has significantly improved outcomes for patients with advanced malignancies. However, a substantial proportion of patients either do not respond to these therapies or eventually develop resistance. Combining immunotherapies that target distinct immunosuppressive mechanisms may enhance treatment efficacy or circumvent resistance.Tumor-associated macrophages (TAMs) are educated by the tumor microenvironment to adopt a tolerogenic phenotype, promoting tumor progression. These cells constitute the predominant immune infiltrate within tumors, making them a highly promising therapeutic target in immuno-oncology.Our goal is to further develop a novel, first-in-class immunotherapy targeting TAMs. We identified a critical checkpoint in the induction of tolerogenic macrophages, with great potential for many solid tumors. We are performing studies in TAM biology, consisting of clinical observations, basic research and mathematical modelling, to contribute to the development of a new monoclonal antibody-based therapy, which is able to reprogram TAMs from their tolerogenic state to a pro-inflammatory one. These analyses will be combined with preclinical studies in mice; we have shown that administration of our therapy alters the intratumoral microenvironment, changing the immune cell population profile (including TAM phenotype), decreasing blood vessel abundance, and increasing the inflammatory milieu, to overall reduce tumor progression.We aim at expanding our understanding of TAM biology, advance in the development of our immunotherapy by elucidating its full mechanism of action and potential, and ultimately accelerate the development of an innovative cancer therapy. A distinctive feature of this position is the opportunity for the post-doc fellow to work in close collaboration with TAM Therapeutics, our spin-off dedicated to the regulatory, clinical and commercial development of this research. This synergistic relationship will provide the candidate with invaluable insights into the translational aspects of scientific discovery, bridging the gap between academia and industry. The candidate will thus not only gain expertise in cutting-edge research but also acquire knowledge and skills essential for the practical application of findings in preclinical and clinical settings, significantly enriching their academic and professional development.We look for a highly motivated candidate who wishes to advance her/his scientific career in a friendly and stimulating environment within the field of translational cancer immunology research.MAIN RESPONSIBILITIES:Experimental Work:

• Conduct in vitro functional and phenotypic analysis of macrophages and immune cells in the context of cancer using primary cells and cell lines.
• Participate in the design and execution of preclinical cancer models in mice and sample analysis.
• Investigate biomarker expression in human samples employing techniques such as immunohistochemistry, immunofluorescence, or RT-PCR-Sequencing.

Additional Responsibilities:

• Maintain a comprehensive understanding of the research field through literature review.
• Analyze and interpret experimental data, manuscript preparation.
• Contribute to the mentoring of scientists with less experience in the laboratory.
• Actively participate in laboratory meetings, IGTP seminars, and national/international conferences.

WHAT WE OFFER:

• Full time contract
• Date of incorporation: November_December 2024
• Gross annual remuneration will be fixed based on the experience provided and the skills of the candidate, distributed in 12 payments.
• Flexible payment (childminding vouchers).
• Opportunity to join a team committed to her/his professional development.
• 23 days holiday and 5 days for personal matters.
• Training capsules by the company.
• Be part of an excellent multidisciplinary research centre with the HRS4R badge.
• Location on the Can Ruti Campus, a first-class translational research environment in the Barcelona area, in a very stimulating scientific environment. The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.

Where to apply WebsiteRequirementsResearch Field Biological sciences » Biology Education Level PhD or equivalentResearch Field Medical sciences » Cancer research Education Level PhD or equivalentSkills/QualificationsRequired:

• At the time of recruitment, candidates must hold a PhD degree in biological or biomedical science, in the field of immunology, cancer and/or cancer immunology.
• At least one publication as first author in a Q1/D1 indexed journal.
• Applicants must demonstrate an advanced level of English language (spoken and written).
• Willingness to conduct preclinical studies in mice with adequate support.

Valued:

• Participation in national/international conferences.
• Proven ability to communicate complex scientific information clearly and concisely, and to work collaboratively within a research team.
• Strong ability to manage responsibilities and meet deadlines.
• Organizational, proactive and self-motivated attitude.

Languages ENGLISH Level ExcellentAdditional InformationBenefitsWHAT WE OFFER:

• Full time contract
• Date of incorporation: November_December 2024
• Gross annual remuneration will be fixed based on the experience provided and the skills of the candidate, distributed in 12 payments.
• Flexible payment (childminding vouchers).
• Opportunity to join a team committed to her/his professional development.
• 23 days holiday and 5 days for personal matters.
• Training capsules by the company.
• Be part of an excellent multidisciplinary research centre with the HRS4R badge.
• Location on the Can Ruti Campus, a first-class translational research environment in the Barcelona area, in a very stimulating scientific environment. The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.

Eligibility criteriaInterested persons must attach to the application:

• Motivation letter explaining their interest in the position.
• Updated CV.
• Contact of 2-3 references.

Selection process

• Curricular evaluation: analysis of the curriculum vitae to assess aspects related to training, professional career and experience in positions related to the job position under selection.
• Personal interview: once the résumé has been evaluated, the selected candidates will be called for a personal interview to verify and expand on the information detailed in the résumé and to evaluate aspects related to experience and professional skills.

Applications that do not meet the requirements, that are not included in the cases foreseen or that are not processed in accordance with the established procedure will not be considered in the selection process.DEADLINE FOR APPLICATIONS:The call for applications will close on the 18th of November 2024 and the incorporation will take place after 5 working days in order to be able to complete the necessary formalities.Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute IGTP Country Spain State/Province BARCELONA City BADALONA Postal Code 08916 Street CTRA DE CAN RUTI/ CAMI DE LES ESCOLES S/NContact State/ProvinceBARCELONA CityBADALONA WebsiteStreetCTRA DE CAN RUTI/ CAMI DE LES ESCOLES S/N Postal Code08916 E-Mailseleccion@igtp.catSTATUS: EXPIREDShare this page

Expected salary

Location

Badalona, Barcelona

Job date

Sat, 09 Nov 2024 00:53:21 GMT

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