Postdoctoral position on engineering microbial cell factories
VIB
Postdoctoral position on engineering microbial cell factories for the industrial production of high-value natural productsJob description
Are you interested in engineering microbial cell factories for the high-yield production of industrially important natural products? Join our multidisciplinary and international team to perform innovative research aimed at harnessing the biosynthetic power of actinomycetes.
We are looking for a motivated postdoctoral scientist to work on a collaborative project with a leading Active Pharmaceutical Ingredients (APIs) manufacturing company. Our goal is to engineer two actinomycete strains as microbial cell factories to produce an antimicrobial and an agrochemical compound at industrial scale. You will leverage state-of-the-art synthetic biology tools and use advanced, high-throughput metabolic and biosynthetic engineering approaches to efficiently enhance the production levels of these high-value compounds.
You will be based in Leuven, but will also collaborate with our industrial partner via regular online meetings. In this way, your work will have a direct industrial impact, contributing to the development of optimized microbial strains for industrial applications and the synthesis of compounds via precision fermentation.Who we are
The lab of Joleen Masschelein at the VIB-KU Leuven Center of Microbiology is home to a multidisciplinary team of approximately 20 researchers, dedicated to studying and engineering micro-organisms and their secondary metabolites for therapeutic and agrochemical applications. Research in the Masschelein lab spans the exciting interface between chemistry & biology and centers around discovering new bioactive natural products from bacteria, elucidating unusual pathways for natural product biosynthesis, unravelling the ecological role and mode of action of natural products, and engineering microbial cell factories for therapeutic and industrial applications. To accomplish this, we combine microbiology, molecular genetics, genomics, enzymology, bioinformatics, structural biology, analytical chemistry and chemical synthesis. For more information on our lab and publications, please visit https://masscheleinlab.sites.vib.be [https://masscheleinlab.sites.vib.be/] .
Our lab hosts state-of-the-art synthetic biology and analytical chemistry facilities for high-throughput (i) biosynthesis, detection, isolation and structural characterization of microbial metabolites; (ii) protein purification and in vitro biochemical assays; and (iii) the growth and genetic manipulation of aerobic and anaerobic micro-organisms.
The lab is part of the VIB Life Sciences Institute and is located at KU Leuven, one of the oldest and most prominent universities in Europe, consistently ranked within the top 50 universities Worldwide. The lab is situated in the beautiful park of the 15th-century Arenberg castle in Heverlee, near the city center of Leuven. Leuven is located 10 miles from Brussels, with frequent direct train connections to Brussels airport. It is a picturesque, historic university city with a young and vibrant atmosphere and a strong international allure. Profile
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Louvain, Brabant Flamand
Tue, 18 Jun 2024 22:35:10 GMT
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