Postdoctoral Position (funded by Worldwide Cancer Research)

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Postdoctoral Position (funded by Worldwide Cancer Research)

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Job description

Offer DescriptionThe Oncogenes and Effector Target (OnTarget) group is looking for a postdoctoral scientist to lead a project aimed at the characterization of a new combination strategy based on KRAS inhibitors for the treatment of pancreatic cancer.The project will require, among other tasks: testing of novel combinatorial therapies using in vitro (cell viability, cell cycle, apoptosis, time-to-progression assays) and in vivo (human cell- and patient-derived xenografts, mouse allografts) models, dissection of the mechanism of action of drug combinations or nominated genes using high-throughput (RNAseq, scRNAseq, ChIPseq, WES, multiplex cytometry and IF, proteomics and/or metabolomics) and focused (Western blot, qPCR) approaches.Our work aims to understand the underlying mechanisms involved in mutant KRAS-driven oncogenesis around two unresolved aspects of KRAS biology: 1) the identification of key transcriptional and functional mediators of cancer initiation and progression, and 2) the discovery of novel therapeutic approaches and the characterization of resistance mechanisms.The project is in line with previous studies by the group (Macaya et al, Nat Comms 2023; Entrialgo-Cadierno et al, Mol Cancer 2023; Erice et al, Clin Cancer Res 2023; Vallejo et al, J Hepatology 2021; Valencia et al, J Clin Invest 2020; Vallejo et al, Nat Comms 2017; Roman et al, Mol Cancer 2018; Roman et al, Cancer Res 2018) and will be carried out within the framework of the new Comprehensive Cancer Center of the University of Navarra (CCUN). The project will provide opportunities for interaction with other groups (internally, nationally and internationally) as well as industry partners.This is a three-year contractfunded by Worldwide Cancer Research, extendable for an additional year pending on additional funding obtained by the candidate.

Where to apply WebsiteRequirementsResearch Field Biological sciences » Biology Education Level PhD or equivalentSkills/Qualifications– PhD in biological or biomedical sciences.– Self-motivated, resilient, autonomous person with team work and communication skills, and the ability to effectively communicate with different research groups (basic scientists, computational biologists, oncologists).– Background in Cancer Biology and/or Immunotherapy is preferred, and experience with mouse work is required.– Initiative and willingness to lead the project and supervise in-training students.– At least one first-author publication in respected journals (excluding MDPI portfolio).Specific Requirements

• Note: If a CV and letter of recommendation are requested, please indicate the e-mail address to which it should be sent (CV cannot be uploaded on the platform unless you are registered with infojobs). It is recommended to use the researcher’s email address to manage offers. If you prefer to use another email address, you can use

as the contact email address. * Interested applicants should send a cover letter describing past experience and interests to:
. * The start date is April 1, 2025, and applications will be considered until February 28th, 2025 (or until the position is filled).Languages ENGLISH Level GoodResearch Field Biological sciencesAdditional InformationWork Location(s)Number of offers available 1 Company/Institute Cima University of Navarra Country Spain State/Province Navarra City Pamplona Postal Code 31008 GeofieldContact State/ProvinceNavarra CityPamplona WebsiteStreetPio XII, 55 Postal Code31008 E-Mailproyectoscima@unav.esSTATUS: EXPIREDShare this page

Expected salary

Location

Pamplona, Navarra

Job date

Wed, 11 Dec 2024 03:05:41 GMT

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