Postdoctoral fellow in the analysis of Spatial Omics data
Offer Description→ Apply before 15/08/2024 (DD/MM/YYYY) 23:59 (Brussels Time)
→ Faculty of Sciences
→ Department: WE02 – Toegepaste Wiskunde, Informatica en Statistiek
→ Occupancy rate: 100%
→ Number of positions: 1
→ Type of employment: Contract of unlimited duration with clause
→ Term of assignment: 2 jaar
→ Wage scale: PD1 to PD4 (doctoral degree)
→ Required diploma: PhDABOUT GHENT UNIVERSITYGhent University is a world of its own. Employing more than 15,000 people, it is actively involved in education and research, management and administration, as well as technical and social service provision on a daily basis. It is one of the largest, most exciting employers in the area and offers great career opportunities. With its 11 faculties and more than 80 departments offering state-of-the-art study programmes grounded in research in a wide range of academic fields, Ghent University is a logical choice for its staff and students.PROJECT OVERVIEWThe and the at the VIB Inflammation Research Center in Ghent, Belgium, are seeking a highly motivated and talented postdoctoral fellow to develop and apply cutting-edge algorithms for the automated analysis of spatial omics data. Join our vibrant research environment and contribute to pioneering projects in bioinformatics and computational biology.Project Overview: This postdoctoral position is part of a larger project aimed at developing novel computational methods for spatial biology, establishing the new field of next-generation molecular pathology. Your research will focus on answering critical questions related to both healthy and diseased liver, utilizing data from improved wet-lab protocols from multiple biological models, complemented by in-house generated spatial omics data with optimized RNA & Protein marker panels (MERFish Vizgen, MACSima Miltenyi,). More details on the project can be found below.Project details: With the development of powerful instruments that can measure the spatial distributions of hundreds of RNA molecules (e.a. MERSCOPE instrument), proteins (e.a. MACSima instrument) or metabolites (e.a. MALDI instruments), the technological challenge has moved from the ability to acquire multiplexed spatial data to the capacity to efficiently integrate and analyze these datasets and this will require the development of novel AI-driven computational pipelines.Our aim will be to develop novel AI-driven algorithms that can extract two key spatial features from tissue sections: (i) the fundamental morphological and pathological features of the tissue (tissue architecture) and (ii) the spatial organization of the cells representing the building blocks of the tissue of interest, including their precise identities and activation states (cellular organization). To achieve this goal the host labs are developing improved wet-lab protocols that allow the co-detection of RNA & Protein markers in fresh-frozen, PFA-fixed or FFPE-fixed preclinical mouse and clinical human liver samples. This will be complemented with tailored spatial multi-omic panels of RNA & Protein markers that enable identifying each of the cells within the tissue, their activation states, precise location and cellular neighbors. Altogether, the aim of the project will be to combine improved wet-lab protocols and matching optimized RNA & Protein marker panels with the development of novel AI-driven computational pipelines that can efficiently process the spatial datasets and extract meaningful biomedical insights automatically.YOUR TASKS
WHAT WE ARE LOOKING FOR
WHAT WE CAN OFFER YOU
(in Dutch).INTERESTED?Apply online through the e-recruitment system before the application deadline (see above). We do not accept late applications or applications that are not submitted through the online system.Your application must include the following documents:
Note that the maximum file size for each field is 10 MB.As Ghent University maintains an equal opportunities and diversity policy, everyone is encouraged to apply for this position.MORE INFORMATIONFor further information and questions, please send an email to Yvan Saeys ( ). Important: do NOT send your application by email, but apply online.Do you have a question regarding the online application process? Please read the or contact us via or +32 9 264 34 36Where to apply WebsiteRequirementsResearch Field Biological sciences Years of Research Experience 4 – 10Research Field Biological sciences Years of Research Experience 4 – 10Research Field Computer science Years of Research Experience 4 – 10Research Field Medical sciences Years of Research Experience 4 – 10Additional InformationWebsite for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Ghent University Country Belgium City Ghent Postal Code 9000 Street Sint-Pietersnieuwstraat 33Contact CityGhent WebsitePostal Code9000STATUS: EXPIREDShare this page
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