Postdoc vacancy in Peeper Lab for ERC Advanced project

Job title:

Postdoc vacancy in Peeper Lab for ERC Advanced project

Company:

Job description

Offer DescriptionThe Netherlands Cancer Institute (NKI) Located in Amsterdam, NKI is an internationally renowned institute dedicated to fundamental, translational and clinical cancer research, and the only comprehensive cancer center in The Netherlands. It is a dynamic institute accommodating over 50 research groups and many advanced core facilities, including flow cytometry, proteomics, genomics, biobank and a mouse cancer center.Project information T cell dysfunction is a key problem in cancer, enabling not only tumorigenesis but also causing resistance to immunotherapy. A better mechanistic understanding is imperative for improving immunotherapy. We recently received an ERC Advanced grant for “ReverT”, a function-based genetic CRISPR-Cas9 screening program to identify genes, ablation of which reverses T cell dysfunction in vivo. This will be done in a pooled and multimodal fashion, analyzing multiple dysfunction phenotypes in parallel, like immune checkpoints, exhaustion, metabolism, recruitment and proliferation. We have already identified several exciting candidates, including “nodal” factors, operating in several seemingly different dysfunction settings. We will use a collection of ex patient tumor models for validation and mechanistic characterization. Lastly, we will translaRequirementsSpecific RequirementsAn ambitious postdoctoral fellow in immunologyWe seek a highly ambitious postdoc with a strong background in immunology and an interest in fundamental and translational cancer research. Your responsibilities will include writing of manuscripts and grant applications. Proficiency in English and good communicative skills are important requirements, as is a team player mentality.Additional InformationBenefitsYou will be employed for a minimum period of 2 years, with the possibiltiy for extension. The gross salary per month is €4.324,- to €4.842 ,- according to salary scale FWG 55, depending on your experience. The terms of employment will be in accordance with the CAO Hospitals and includes an end-of-year bonus and holiday pay. Acquisition for this vacancy is not appreciated.Selection processInterestedApplications should include your CV, a motivation letter and references. Apply via the application button above.The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labor market, sexual orientation or gender identity.

Acquisition for this vacancy is not appreciated.Additional commentsInterestedFor further information and addresses visit our websites:Applications should include your CV, a motivation letter and references. Apply via the application button below.Select reading1: Lin CP et al, Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness. Cancer Cell. 2024
2: Ibáñez-Molero et al, Phosphoprotein dynamics of interacting T cells and tumor cells by HySic. Cell Rep. 2024
3: Kenski et al, An adverse tumor-protective effect of IDO1 inhibition. Cell Rep Med. 2023
4: Zhang et al, RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells. Cell Rep Med. 2022
5: Vredevoogd et al, Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell. 2019The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labor market, sexual orientation or gender identity.Acquisition for this vacancy is not appreciated. Website for additional job detailsWork Location(s)Number of offers available 3 Company/Institute The Netherlands Cancer Institute Country Netherlands City Amsterdam Postal Code 1066 CX Street Plesmanlaan 121 GeofieldWhere to apply WebsiteContact CityAmsterdam WebsiteStreetPlesmanlaan 121 Postal Code1066 CXSTATUS: EXPIRED

Expected salary

€4324 – 4842 per month

Location

Amsterdam, Noord-Holland

Job date

Sat, 20 Apr 2024 06:43:40 GMT

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