Job title:
Postdoc to study the role of Tau, MEG3, and necroptosis in Alzheimer’s Disease
Company:
Job description
Offer DescriptionThe candidate will use human iPS cells both in vitro and in vivo using xenografted mouse models of Alzheimer’s disease (see Balusu et al., Science 2023) to gain further insight into this defining axis of pathology in Alzheimer’s disease, which has also high relevance for the development of drugs for this devastating disease.
Additional information may be found in the following selected references from the lab:
- Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology. Nat Neurosci. 2024. PMID: 38539015
- MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease. Science. 2023 Sep 15;381(6663):1176-1182. PMID: 3770827
- The Cellular Phase of Alzheimer’s Disease. Cell 164(4):603-15. 2016. PMID: 26871627 Review.
Where to apply WebsiteRequirementsResearch Field Neurosciences Education Level PhD or equivalentLanguages ENGLISH Level GoodResearch Field Neurosciences Years of Research Experience 1 – 4Additional InformationBenefits
- An exceptionally strong scientific environment
- Possibility to supervise students and technicians and develop an independent research profile
- Access to state-of-the-art infrastructure
- A stimulating, diverse international research environment in a world-class academic laboratory
- Animal models, expertise in neurodegenerative disorders
- Financial support is available for at least 2 years (renewable one-year contract). However, the successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO, or National funding organizations).
- Start date: as soon as possible – the position is available immediately
Eligibility criteriaRequired
The successful candidate:
- Should hold a PhD degree in neuroscience, biology or a related field
- Should be creative, enthusiastic, and critically thinking
- Enjoys teamwork and has excellent oral and written communication skills in English.
Appreciated
- Experience working with laboratory mice
- Project management and effective communication skills
- Knowledge of the literature on neurodegenerative disorders
- Knowledge of non-coding RNA
- Good understanding of the endo-lysosomal pathway
- Experience working with iPSC cells
- Good publication record
Selection processMotivated candidates with a strong interest in neurodegeneration and with a strong commitment to basic research are invited to apply. Please complete the online application procedure and include a CV, a list of publications, a summary of past research and the contact information of 2 to 3 referees. The best-ranked candidates will be invited for an interview.
For more information please contact Prof. dr. Bart De Strooper, mail: .
You can apply for this job no later than 21/07/2024 via theWork Location(s)Number of offers available 1 Company/Institute KU Leuven Country Belgium State/Province Vlaams Brabant City Leuven Postal Code 3000 Street Leuven GeofieldContact State/ProvinceLeuven CityVlaams Brabant StreetLeuven Postal Code3000 E-Mail[email protected]STATUS: EXPIREDShare this page
Expected salary
Location
Louvain, Brabant Flamand
Job date
Wed, 03 Jul 2024 06:54:11 GMT
To help us track our recruitment effort, please indicate in your email/cover letter where (vacanciesineu.com) you saw this job posting.
