Postdoc position on the neurotoxicity of pesticide mixtures

Job title:

Postdoc position on the neurotoxicity of pesticide mixtures

Company:

Job description

Offer DescriptionWe are being exposed to increasingly complex mixtures of pesticides from our environment. There is great concern that these exposures contribute to the increase in neurodevelopmental diseases in humans, such as Parkinson’s Disease. Novel approaches are urgently needed to predict the effect of pesticides on the developing brain, and to explore their impact on neurodegeneration.In this 2-year postdoctoral project, you will use the nematode Caenorhabditis elegans to explore the impact of environmentally relevant pesticides on neurodevelopment and the progression of Parkinson’s Disease. To achieve this goal, we combine microscopy, developmental assays and molecular biology techniques, such as RNAseq. You will also work with chemists to relate the adverse effects to external and internal pesticide concentrations, thus contributing to the development of (quantitative) Adverse Outcome Pathways. You will develop a longitudinal imaging platform to assess the development of α-synuclein aggregation, a key hallmark of Parkinson’s Disease, throughout the lifespan of the worm. As C. elegans has a relatively simple nervous system, we foresee the use of the nematode to gain additional information as to how pesticides impact neurobehavior, motor function and cognition.For this project, we are looking for a postdoctoral researcher to work on location at the VU in Amsterdam. You will be part of the Environmental Health and Toxicology group of A-LIFE within the VU, under the supervision of Dr. Samantha Hughes. Together with the team, you will present your results at national and international conferences, and in relevant scientific journals.Your duties

  • You will work in the lab with Caenorhabditis elegans to explore the impact of pesticide mixtures on neurodevelopment.
  • Design and run the experiments to elucidate the impact of pesticides on (neuro)development and neurodegeneration
  • Organise your work independently
  • Communicate the results in a transparent and professional manner
  • Supervise undergraduates and PhD students, where appropriate

Where to apply WebsiteRequirementsSpecific Requirements

  • you have a PhD in (applied) biology, biochemistry, developmental biology, or a related field
  • you will have experience working with C. elegans
  • you have good wet lab experimental skills, with experience of molecular and cell biology essential
  • you are a highly motivated, proactive and dedicated individual who is a critical thinker
  • Excellent oral and written communication skills in English
  • A team player who can work independently in an international team

Additional InformationBenefitsEen uitdagende functie bij een maatschappelijk betrokken organisatie. Bij de VU draag je bij aan onderwijs, onderzoek en dienstverlening voor een betere wereld. En daar mag wat tegenover staan. Daarom bieden wij jou:

  • Een salaris van minimaal € 3.226,00 (Schaal 10) en maximaal € 5.090,00 (Schaal 10) bruto per maand, bij een voltijds dienstverband. Dit is gebaseerd op het UFO-profiel Onderzoeker 4. Het precieze salaris hangt af van je opleiding en ervaring.
  • Een functie voor minstens 0,8 fte. Je arbeidsovereenkomst duurt in eerste instantie 2 jaar.

Daarnaast bieden wij je aantrekkelijke secundaire arbeidsvoorwaarden en regelingen. Enkele voorbeelden:

  • Bij een voltijdse 38-urige werkweek hoort een vakantietegoed van 232 uur per jaar. Als je ervoor kiest om 40 uur te werken, beschik je op jaarbasis over 96 extra vakantie-uren. Bij een deeltijdaanstelling wordt dit naar rato berekend.
  • 8% vakantietoeslag en 8,3% eindejaarsuitkering
  • kinderdagverblijf aanwezig op VU campus
  • keuzemodel voor fiscale uitruil van bepaalde arbeidsvoorwaarden
  • goede en voordelige sportfaciliteiten

Additional commentsBen jij enthousiast over deze positie en overtuigd dat jouw expertise bijdraagt aan de verdere ontwikkeling van onze universiteit? Dan nodigen wij je graag uit om te solliciteren.Het overleggen van een diploma, een referentiecheck en een assessment maken onderdeel uit van de sollicitatieprocedure.Sollicitaties ontvangen per e-mail worden niet in behandeling genomen.Acquisitie naar aanleiding van deze advertentie wordt niet op prijs gesteld. Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Vrije Universiteit Amsterdam Country Netherlands City Amsterdam Postal Code 1081HZ Street De Boelelaan 1108 GeofieldContact CityAmsterdam WebsiteStreetDe Boelelaan 1105 Postal Code1081 HVSTATUS: EXPIREDShare this page

Expected salary

Location

Amsterdam, Noord-Holland

Job date

Fri, 30 Aug 2024 06:15:12 GMT

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