Job title:
Postdoc (M/F) in biology of the cell cycle of P. berghei parasites
Company:
Job description
Offer DescriptionAll eukaryotic cell multiplication requires well-orchestrated developmental programs and regulatory pathways to guarantee fidelity in transmission of genetic information. Multiplication inside red blood cells of Plasmodium falciparum, the deadliest malaria parasite, is responsible for malaria pathogenicity. Unlike model organisms, Plasmodium divides in unconventional ways producing not two but up to tens of thousands of daughter cells, in a single cell cycle round. This points to a yet-to-be-explored original and divergent cell cycle architecture where conventional rules likely do not apply.We study different aspects of the cell cycle of malaria parasites. We are especially interested in understanding the regulatory network orchestrating the original cell cycle that characterises malaria parasites and how checkpoint like decisions are made throughout schizogony. For that we use cell and molecular biology, genetics, proteomics and advanced transcriptomics.
We combine the strenghts of two different models: Plasmodium falciparum and Plasmodium berghei to perform either in vivo or in vitro large scale studies.We are seeking a highly motivated postdoctoral researcher to join our team at LPHI in Montpellier, France. The successful candidate will lead an exciting ERC-funded project (JANUS 2024-2029) investigating the cell cycle of malaria parasites using cutting-edge genetics and omics techniques.LPHI is a French Unité Mixte de Recherche CNRS (UMR 5294) – INSERM (UA 15) – Université de Montpellier, dedicated to the study of infectious microbes and host immune response. Research at LPHI aims at gaining a deeper understanding of how microbial pathogens develop and interact with their host, in order to identify new potential targets for therapeutics. The institute is part of a campus that has state of the art facilities including microscopy, flow cytometry, proteomics, sequencing and a high-performance computing cluster.
The LPHI is involved in several local, national and international networks like the University of Montpellier BioHealth Department, the Eurobiomed competitiveness cluster, the Infectiopôle Sud Foundation, the Parafrap Laboratory of Excellence, the FHU-TIE (Fédération Hospitalo-Universitaire -Triangulation between the host, Infectious agents and the Environment) or the INFLANET European Training Network.
We strive to create an environment where all individuals are valued, respected, and supported.For more info:Where to apply WebsiteRequirementsResearch Field Biological sciences Education Level PhD or equivalentResearch Field Biological sciences Education Level PhD or equivalentLanguages FRENCH Level BasicResearch Field Biological sciences Years of Research Experience NoneResearch Field Biological sciences » Biology Years of Research Experience NoneAdditional InformationEligibility criteriaThe postdoctoral researcher will:
- Optimise and perform the first genome wide reverse genetics screen with single cell resolution in a malaria parasite using P.berghei asexual blood stages as model.
- Integrate multi-omics data to gain comprehensive insights into parasite biology
- Follow up of screening candiates using reverse genetics and dissect the intricate cell cycle regulatory mechanisms of Plasmodium berghei.
- Collaborate with other lab members on interdisciplinary projects to enhance our understanding of malaria biology
- Mentor and train graduate and undergraduate students in experimental techniques and/or data analysis
Qualifications:
- Ph.D. in Molecular Biology or Parasitology
- Strong background in genome wide screening approaches
- Excellent problem-solving skills and ability to lead a challenging research project
- Excellent written and verbal communication skills in English
- Ability to work independently and as part of a collaborative team
- Commitment to diversity, equity, and inclusion in the research environment.
Preferred skills:
- Experience in parasitology research
- Expertise in technology development
- Familiarity in bioinformatics and data analysis
- Holder of a FELASA rodents animal license
Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Laboratory of Pathogens and Host Immunity Country France City MONTPELLIER GeofieldContact CityMONTPELLIER WebsiteSTATUS: EXPIREDShare this page
Expected salary
Location
Montpellier
Job date
Thu, 09 Jan 2025 08:42:56 GMT
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