Postdoc in applied machine learning
Københavns Universitet
We are looking for a highly motivated and dynamic postdoc for a postdoctoral researcher for two years, starting on the 1 August 2024. The postdoc will join BarleyMicroBreed, a large European Commission funded project containing 12 different commercial and academic partners across Europe and North Africa. The goal of the project is to identify genes in barley that can ultimately be selected for in breeding programmes to promote drought tolerance (by them using microbes more effectively). The candidate in this position will be responsible for applying statistical learning approaches on barley genome data, microbial communities and plant phenotypic data to identify links between them that can be later explored in the lab.Information on the department can be found at .Our research
This project will be hosted within The Plant Hologenome group led by Associate Professor Christopher Barnes ( ), which operates within the Centre for Evolutionary Hologenomics (CEH) ( ). In our centre, we believe that microbes are essential to the life of multi-cellular organisms, and if we are to fully understand the differences between individuals, both the host genome and the microbiome effects need to be considered. However, these interactions are so complex, we generate large datasets (multi-omic data) and develop methods for their integration. This area is so expansive, we rely upon collaboration to for projects to succeed, and we therefore emphasise this within a work environment. The CEH is a diverse and vibrant environment, with researchers having various different research and personal histories. Furthermore, within the CEH we have access to world class molecular laboratories (for data production) and a new custom-built server for processing massive -omics era datasets.The project
Barley is the ‘last crop before the desert’, meaning if barley cannot grow, the land be quickly become unusable for the foreseeable future. While there are barley lines that are extremely drought tolerant, they are not the most productive ones. We hypothesise that some of the toughest barley lines’ resilience comes from their root microbiome, where they cultivate microbes that then help in surviving drought. If we can therefore identify the genes and microbes associated with enhanced drought tolerance and breed them into highly productive lines, we can ensure future production even in light of increasing drought severity and intensity with climate change.Your job
Specifically, you will take barley genome data (and SNPs, SNVs, indels etc.) and integrate it with metagenomic data from roots and phenotypic data (root morphological traits and total biomass) which were collecting from multiple field sites. You will take the lead in performing this, which can be performed in many ways. However ongoing projects within the centre are using variance auto-encoders and structural causal modelling, which could serve as a basis for the analyses here. The candidate will be able to work with bioinformaticians, statisticians and plant biologists across different research groups within the centre in order to achieve this. We will later test the effects of your predicted gene-microbiome interactions by manipulating the genomes of barley plants with CRISPR/Cas and growing mutants in controlled environments. If successful, we will eventually breed these genes into high yielding barley lines to improve their drought tolerance (i.e. without genetic medication).Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:Essential experience and skills:
Desirable experience and skills:
Place of employment
The place of employment is at the Centre of Hologenomics, the Globe Institute, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include world class modern laboratories, various next generation sequencing platforms, high performance computing clusters, in house bioinformaticians and biostatisticians.About Globe Institute
The Globe Institute is part of the Faculty of Health and Medical Sciences at the University of Copenhagen. The Institute’s main purpose is to address basic scientific questions through interdisciplinary approaches. The institute operates at the intersection of natural and medical sciences and the humanities. Information on the institute can be found at: .
Deadline for applications: 21 april 2024, 23:59 CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.You can read about the recruitment process atThe applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.
København
Fri, 22 Mar 2024 06:28:07 GMT
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