Postdoc/assistant professor

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Postdoc/assistant professor

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Offer DescriptionProject title: Understanding multi-scale innate immune defences against bacterial pathogens at the single-cell levelWe are seeking an enthusiastic and highly motivated computational scientist to join a laboratory of Prof. Pawel Paszek at IPPT PAN to investigate mechanisms involved in the muti-scale coordination of innate immune responses against bacterial pathogens.The project focuses on interactions between innate immune macrophages and the important food-borne bacteria Listeria monocytogenes that causes significant levels of human morbidity and mortality. Our main goal is to elucidate how pathogen threats are encoded in dynamical responses of NF-kB/STAT/IRF systems upon infection.We use interdisciplinary approaches combining experimental and theoretical systems biology apprach. These include live-cell microscopy to monitor the activation of the antibacterial NF-kB/STAT/IRF signaling systems in individual host cells in real-time together with L. monocytogenes growth and virulence.Successful candidate will use data generated in the project to build dynamical mathematical models of infection.Where to apply E-mailkonkursy@ippt.pan.plRequirementsResearch Field Biological sciences » Biological engineering Education Level PhD or equivalentResearch Field Engineering » Biomedical engineering Education Level PhD or equivalentResearch Field Technology » Biotechnology Education Level PhD or equivalentResearch Field Mathematics » Applied mathematics Education Level PhD or equivalentResearch Field Physics » Biophysics Education Level PhD or equivalentResearch Field Computer science » Programming Education Level PhD or equivalentSkills/QualificationsWe seek candidates having experience and publication record in at least one of the following areas:

• Mathematical biology, systems biology, applications of ordinary and partial differential equations / stochastic simulations to describe biological/cellular processes, modelling of signaling pathways modelling.
• Image analysis, machine learning, statistical data analysis.
• Programming in Python, Matlab.

Experience in collaborating with experimental scientists or experience in experimental cell biology will be considered beneficial.Specific RequirementsSuccessful candidate will analyze and use high-content microscopy data generated in the project to develop mathematical models of innate immune response. She or he will be expected to:

• Use differential equations and stochastic simulations to describe activation of the immune response in heterogeneous cell populations, cellular communication, different outcomes of infection (eradication, persistence, replication), regulation of bacterial virulence. Models might account for spatial aspects of the cytokine diffusion and bacterial spread.
• Perform experimental data analysis, in particular high-content microscopy data, machine learning, statistical analysis and image analyses.
• Use Python and Matlab for high content data analysis and modelling.

Languages ENGLISH Level ExcellentResearch Field Biological sciences » Biological engineeringEngineering » Biomedical engineeringTechnology » BiotechnologyMathematics » Applied mathematicsPhysics » BiophysicsComputer science » Programming Years of Research Experience 4 – 10

Additional InformationBenefits

• We offer remuneration of approximately 9300 PLN/month gross (including previous experience) for 26 months (with possible extension for 36 months).
• The project provides unique opportunities for interdisciplinary research in the field of infection biology.
• Working with high-class research equipment with experienced staff as a member of Laboratory of Modelling in Biology and Medicine (

).IPPT PAN is a top interdisciplinary research institute in Poland located in a beautiful and very international city, Warsaw.Eligibility criteriaCandidates must hold a PhD degree (obtained in 2017 or later) in a relevant field and have excellent track record for their career stage.Selection processPlease provide the following documentation with your application:1. Copy of PhD diploma in relevant field (obtained no earlier than in 2017). MSc and Bachelor diplomas may be also included for evaluation.2. CV containing information about:

• Publications,
• Conference presentations,
• Prizes and stipends,
• Other information that can help in evaluation, like experience, achievements, and scientific standing of the candidate.
• Contact details for two references,
• Please include in your CV the following clause: “I agree to the processing of personal data contained in my job offer for the needs necessary to carry out the recruitment process conducted by IPPT PAN with headquarters in Warsaw, ul. A. Pawińskiego 5B, according to art. 13 para. 1 and 2 of Regulation (EU) 2016/679 of the Parliament and of the Council of 27 April 2016 on the protection of individuals with regard to the processing of personal data and the free movement of such data and the repeal of Directive 95/46 / EC (RODO).

3. Motivation letter (1 page).The documents should be sent to , with a copy to Project PI, Pawel Paszek and Department Secretary Ms. Agnieszka Ponarska ( ). Suitable candidates will be contacted and invited for an interview.In your application, please indicate the competition number BSP-DSP.111.28.2024Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Institute of Fundamental Technological Research Polish Academy of Sciences Country Poland State/Province Mazovia City Warsaw Postal Code 02-106 Street A.Pawińskiego 5BContact State/ProvinceMazovia CityWarsaw WebsiteStreetA.Pawińskiego 5B Postal Code02-106 E-Mailamilcz@ippt.pan.plSTATUS: EXPIREDShare this page

Expected salary

Location

Warszawa, mazowieckie

Job date

Sat, 21 Sep 2024 22:37:02 GMT

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