Technical University of Munich
20.04.2023, Wissenschaftliches Personal
To strengthen our team, we are recruiting a highly motivated
PostDoc and Ph.D. student in biology with computational background
About the lab
The successful candidate will be part of the Andergassen lab based at the Institute of Pharmacology and Toxicology of the Technical University of Munich (TUM). The lab bridges computational (allele-specific epi-genomics) and experimental strategies (high-throughput bulk/single-cell sequencing, CRISPR in vivo editing) to understand the functional contributions of the non-coding genome, such as long non-coding RNAs on cardiovascular diseases (CVD). Furthermore, we aim to elucidate the contribution of sex chromosomes to sex differences in CVD. Particular attention is given to those genes that escape female X chromosome inactivation, resulting in a higher gene dose in females (XX) than males (XY). To systematically elucidate the molecular mechanisms for the CVD sex bias, the lab quantitatively assesses the impact of sex chromosomes and hormones by combining allele-specific genomics with disease and genetic mouse models. The lab aims to reveal relevant therapeutic candidates and new regulatory disease mechanisms forming the foundation of new sex-specific therapies for treating CVD in humans. More information: www.andergassenlab.com and https://www.professoren.tum.de/en/tum-junior-fellows/andergassen-daniel
About the institute
The Institute of Pharmacology and Toxicology (IPT) is part of the Medical Faculty of the Technical University of Munich (TUM), one of the leading universities in the European Union. The institute’s research focuses on non-coding RNAs, their control of cardiac gene expression, and the effects of their therapeutic manipulation in cardiac disease. The institute’s state-of-the-art research facility includes a fully equipped mouse cardiac phenotyping lab, a viral vector core, and the entire experimental pipeline for next-generation sequencing from tissue or single-cells, including FACS-based cell separation. Furthermore, the IPT coordinates and receives funding from the DFG Collaborative Research Center TRR267 “Non-coding RNA in the Cardiovascular System” and is the Munich partner site of the German Center for Cardiovascular Research (DZHK). The outstanding infrastructure and experience present in the institute provide an ideal environment for a project to succeed. More information: www.ipt.med.tum.de
● We are looking for a variety of academic backgrounds: molecular biology, biomedical research, bioinformatics
● You hold a Ph.D. in molecular biology and have a computational background (applies for the PostDoc applicant)
● You must have at least one first-author publication (applies for the PostDoc applicant)
● You hold a master’s in molecular biology and have a computational background (applies for the Ph.D. applicant)
● Solid wet-lab experience and experience in library preparation for next-generation sequencing
● Experience working in a Linux/Unix environment and R programming
● Hands-on experience from working with sequencing data
● Written and oral communication skills in English
● Highly motivated scientist and commitment to scientific excellence
● 3-year contract with the possibility to prolong (payment according to TV-L E13)
● State-of-the-art facility in house such as mouse phenotyping, viral vector core, in vivo editing core, single-cell platform, hiPS cell culture
● Access to the Leibniz-Rechenzentrum (LRZ)
● A highly motivated and international institute with a high PostDoc to student ratio
● Membership in the TUM Graduate School and benefit from educational programs
The TUM aims to increase the diversity of its staff substantially. As an equal opportunity and affirmative action employer, the TUM explicitly encourages nominations of and applications from women and all others who would bring additional diversity dimensions to the university’s research and teaching strategies.
Please send your complete application documents (cover letter, C.V., certificates) via email to:
Daniel Andergassen Ph.D.
TUM, Institute of Pharmacology and Toxicology
Biedersteiner Strasse 29, 80802 Munich, Germany
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Kontakt: [email protected]
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