Post-doctoral Researcher- the impact of UPF1 ATP mimetics on the mutant immunopeptidome

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Post-doctoral Researcher- the impact of UPF1 ATP mimetics on the mutant immunopeptidome

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Job description

Offer DescriptionWe are looking for a post-doc to work in the International Centre for Cancer Vaccine Science (ICCVS) hosted by the University of Gdańsk. The position is offered in the frame of the project “The impact of UPF1 ATP mimetics on the mutant immunopeptidome”. The project is funded by the National Science Centre within the programme OPUS under grant agreement no. UMO-2020/39/B/NZ7/02677.About the projectThe postdoctoral researcher will work within the project: The impact of UPF1 ATP mimetics on the mutant immunopeptidome led by prof. Theodore Hupp (grant agreement: UMO-2020/39/B/NZ7/02677). The project is a bilateral cooperation with the Gdańsk University of Technology, funded by NCN within the funding programme OPUS. The project focuses on understanding the mechanism and physiological functions of the NMD pathway which can have the potential for treating certain genetic diseases and cancer. Co-authors are dr hab. eng. Umesh Kalathiya from the ICCVS, University of Gdańsk and prof. Sławomir Makowiec from the Gdańsk University of Technology. There is an opportunity to access the Cyfronet Ares (37 824 computing cores and 147,7 TB of RAM) and CI TASK Tryton (~38, 000 cores) supercomputer clusters, which are consistently represented among the top 500 super computers in the world.About ICCVSThe International Centre for Cancer Vaccine Science (ICCVS) has been established in 2017 as a joint unit of the (UG) and the (UoE) within a project carried out within the of the funded from the European Regional Development Fund. The aim of ICCVS has been comprehensive research into development of novel diagnostic and prognostic markers and personalized anti-cancer therapies and vaccines, followed by their commercialization and implementation into clinical practice. ICCVS works on a range of national and international research projects concentrating on cancer biology and novel approaches to immunotherapies. The focus of the ICCVS is the development of personalized vaccine against non-small cell lung cancer (NSCLC). The approach is based on use of cancer specific T cells that are selected by the special algorithm elaborated at ICCVS. The first in vitro and in vivo studies are very encouraging, and the team plans to start clinical trials in a few years perspective.More information:Where to apply E-mailiccvs@ug.edu.plRequirementsResearch Field Biological sciences » Other Education Level PhD or equivalentSkills/Qualifications

• Applying molecular modeling techniques to investigate the targeted NMD components.
• Conducting research within the project.
• Biological evaluation for the selected novel compounds and its derivatives against target; hUPF1 or other components form the NMD process.
• Designing in vitro experiments for the selected ligands (or derivatives) for the UPF1 protein using thermal shift assay or cellular thermal shift assay methods.
• Sample preparation for the CLMS analysis, to identify peptides and proteins.
• Participate in designing experiments for the FRET assay to study interactions between UPF1, UPF2, UPF3a, and UPF3b proteins from the NMD pathway.
• Visualization and presentation of the obtained results during internal meetings as well as scientific conferences.
• Publishing the obtained results in scientific journals.
• Other tasks related to scientific activity under the project defined by the project manager.

Languages ENGLISH Level GoodAdditional InformationBenefits

• Employment contract for up to 11 months (full time, “adjunct” position) with possibility of prolongation, after 3 months initial contract. Salary before tax & social insurance deductions approx. 8.700 PLN (gross).
• Additional yearly remuneration (so-called “13th salary”) if eligible and according to binding provisions at the University.
• Holiday allowance/ Christmas allowance, if eligible and according to binding provisions at the University.
• Possibility of paid participation in private medical insurance, Multisport offer, life insurance.
• Starting date to be discussed, as soon as possible.
• Friendly and inspiring working atmosphere.
• Presentation of work at international and national conferences.
• While employed in this project, the candidate shall not receive remuneration coming from direct costs of other NCN research projects as well as from another employment contract, including an employer from outside Poland.
• In case of questions, you are encouraged to contact dr hab. eng. Monikaben Padariya at

before submitting the application.Eligibility criteria

• Doctoral degree obtained not earlier than 7 years before the year of employment in the project (excluding leaves related to the care and upbringing of children) in an entity other than that in which this position is to be filled, or has completed a continuous and documented postdoctoral training of at least 10 months at an institution other than the entity implementing the project, and in a country other than the country in which the doctoral degree was obtained.
• Understanding of protein dynamics and investigating targeted active / allosteric site pockets is an advantage.
• Knowledge of using and optimizing the thermal shift assay (TSA) to understand the activity of novel hit molecules compounds.
• Understanding of cross-linking mass spectrometry (CLMS) field, to investigate different cancer types treated with novel hit molecules.
• Basic knowledge of using fluorescence resonance energy transfer (FRET) assay to study protein-protein interactions.
• Knowledge of handling biochemical issues and experimental techniques.
• Good knowledge of the English language (written and spoken).

Selection process

• The decision will be made by the Recruitment Committee (RC) established by the Vice-Rector of the University of Gdańsk and chaired by the Project Principal Investigator.
• An interview will be held (online or onsite).
• The RC reserves the right to invite only pre-selected candidates for the interview.
• The RC’s decision is final and is not subject to appeal.
• The RC reserves the right to close the competition without selecting a candidate.

Additional commentsRequired documents: * Curriculum vitae with a list of publications and achievements;

• Motivation letter (including statement of current scientific interests) – up to 2 pages;
• References: contact details (name, affiliation, email) of two senior researchers who can be contacted for references.
• Declaration of the applicant that his work is not financed by other projects of the National Science Center.
• Signed statement on the GDPR information clause for this job offer – template provided here

. * Scan of PhD diploma.Documents referring to items 1-5 should be prepared in English and sent merged as ONE pdf file. Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute University of Gdansk, International Centre for Cancer Vaccine Science Country Poland State/Province Pomorskie City Gdańsk Postal Code 80-822 Street Kładki 24 GeofieldContact CityGdańsk WebsiteStreetBażyńskiego 8STATUS: EXPIREDShare this page

Expected salary

Location

Gdańsk, pomorskie

Job date

Sat, 05 Oct 2024 23:55:05 GMT

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