Post-doctoral position, epilepsy research program

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Post-doctoral position, epilepsy research program

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Job description

Offer DescriptionContextEpilepsies are a group of heterogeneous diseases having in common seizures onset and co-morbidities. Epilepsies affect around 1% of the population with a higher incidence in infants and children, with approximately 80% of these epilepsies initiating in childhood. In addition to medical, social, psychological, and economic burden due to seizures, epilepsies in childhood have a major impact on the neurodevelopment and autonomy in adulthood. To address these major challenges in childhood epilepsies, Innov4-ePiK program will establish game changing approaches to improve the outcome and quality of life of patients with DEEs. This is made possible thanks to the identification of innovative smart biomarkers based on clinical, electrical, biological, and imaging data from patients’ cohorts associated with in silico and in vivo models.ProjectThe main goal of this project is to investigate the physiopathological mechanisms of discovered potassium channel mutations in DEEs using in vitro and in vivo models. The candidate will be able to explore a range of scientific questions using zebrafish genetic models, patient cell lines and organoids with the goal of taking novel genetic discoveries from the mechanistic investigation to therapeutic leads. Our close collaboration with expert technological platforms (e.g. multi-omics, iPSC, imaging, electrophysiology, single-cell analysis, bioinformatics, etc.) allows access to the latest tools for fundamental research, biomarker identification and development of automated drug screening assays leading to in-house clinical applications. The day-to-day collaboration with the reference centre for rare epilepsies team and the lessons learned from the clinical groups and the cohorts’ data collected will accelerate the translation from bench to bed.Your profile

• Highly motivated PhD in molecular biology, genetics, neuroscience or related areas;
• Good publication track record;
• Experimental skills in hiPSC culture will be appreciated;
• Additional skills in epilepsy, animal experimentation (zebrafish) and cell imaging are considered as a plus.
• Team player attitude and problem solving skills;
• Self-motivation and ability to work independently are vital;

(Knowledge of French is not a requirement.)Contract

• Fixed-term contract: 2 years, renewable. During this period, the successful candidate will be encouraged to apply for an external postdoctoral fellowship to pursue the project.
• Starting date: flexible
• Salary: On experience

About usThe team of Dr. Edor Kabashi is involved in all the aspects of translational research in an integrative approach, from a better characterization of patients and their genetic markers to modelling and fundamental research to identify appropriate therapeutic targets, and ultimately developing clinical trials to test novel treatments. This research is highly patient driven, with extensive phenotyping using the multidisciplinary expertise in clinical testing and the state-of-the-art platforms that are available at the Imagine Institute in the Necker Hospital site (e.g. genomic sequencing, electrophysiology, metabolic screening, imaging), while fostering collaborations with a network of national and international collaborations.

Pr. Rima Nabbout, who leads the Reference Center for Rare Epilepsies (CReER) at Necker Hospital, is coordinating the epilepsy research project, bridging the clinical and fundamental aspects for an integrative approach. CReER is internationally renowned for the phenotypic classification of patients, the genetic analysis of large patient cohorts leading to the identification of novel genetic factors and delineating natural history of DEEs based on natural language processing and other AI techniques. Pr Nabbout and team are actively involved in the main orphan drugs and therapies development for rare epilepsies and recognized for spearheading successful clinical trials.Where to apply E-mailjulie.tahraoui@institutimagine.orgRequirementsResearch Field Neurosciences » Neurobiology Education Level PhD or equivalentResearch Field Biological sciences » Biology Education Level PhD or equivalentSkills/QualificationsYour profile

• Highly motivated PhD in molecular biology, genetics, neuroscience or related areas;
• Good publication track record;
• Experimental skills in hiPSC culture will be appreciated;
• Additional skills in epilepsy, animal experimentation (zebrafish) and cell imaging are considered as a plus.
• Team player attitude and problem solving skills;
• Self-motivation and ability to work independently are vital;
• Knowledge of French is not a requirement.

Languages ENGLISH Level ExcellentResearch Field Biological sciences » BiologyNeurosciences » Neurobiology Years of Research Experience 1 – 4Internal Application form(s) neededImagine_PostDoc_Pr.Nabbout.pdfEnglish(131.04 KB – PDF)Additional InformationWebsite for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Imagine Institute Country France City Paris Postal Code 75015 Street Boulevard du Montparnasse GeofieldContact CityParis WebsiteStreetBoulevard du Montparnasse Postal Code75015 E-Mailjulie.tahraoui@institutimagine.orgrima.nabbout@aphp.frSTATUS: EXPIREDShare this page

Expected salary

Location

Paris

Job date

Wed, 17 Jul 2024 02:54:49 GMT

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