PhD student-scholarship holder at the Poznan Doctoral School of Institutes PAS, Dept. of Molecular Pathology
Offer DescriptionThe goal of this project is to develop a novel therapeutic approach for B-cell lymphoma based on targeting the IGH enhancer RNA. To this end, we will conduct a high-throughput screening for small molecules binding to the eRNA transcribed from the essential region in the IGH enhancers. Next, hit compounds will be validated for their effect on lymphoma cell growth and potential toxicity towards normal cells. Finally, selected compounds will be assessed in vivo in mouse xenograft models.Results of our project will indicate novel therapeutic opportunities for treatment of B-cell lymphomas. Our strategy will universally target IGH translocations, regardless of the oncogene involved. This may be especially relevant for the group of so-called double hit B-cell lymphoma patients (with two oncogenes translocated to IGH), who in general respond poorly to current treatment regimens. Results of this pre-clinical proof of concept study will provide novel B-cell lymphoma therapeutics with a direct translation to clinical studies.Keywords:IGH, B-cell lymphoma, enhancer, eRNA, small moleculePredicted tasks in the project:
Where to apply E-mailphdstudies@igcz.poznan.plRequirementsResearch Field Biological sciences » Biological engineering Education Level Master Degree or equivalentSkills/QualificationsCriteria for the evaluation of candidates * Candidate’s scientific and professional experience based on his/her participation in conferences, workshops, training courses and internships; participation in research and commercial projects; involvement in scientific societies and associations; international and professional mobility; experience in other sectors, including industry.
Requirements for candidates * Background in molecular biology.
Specific RequirementsRequired documents * CV, including research achievements.
. * Contact details of at least one current supervisor or other researcher who has previously agreed to issue an opinion about the candidate. The opinion should not be included in the application.
) * Certificates or other documents indicating level of English language proficiency, if the candidate possesses any.Criteria for the evaluation of candidates * Candidate’s scientific and professional experience based on his/her participation in conferences, workshops, training courses and internships; participation in research and commercial projects; involvement in scientific societies and associations; international and professional mobility; experience in other sectors, including industry.
Languages ENGLISH Level ExcellentResearch Field Biological sciences » Biological engineering Years of Research Experience 1 – 4Internal Application form(s) neededIHG_Application_for_admission.pdfEnglish(151.47 KB – PDF)Additional InformationBenefitsDepartment in which candidate will work: Department of Molecular PathologyDiscipline: Medical SciencePlanned remuneration: scholarship to the value of 4300 PLN gross/per month (3800 PLN net /per month) before the mid-term evaluationPeriod of involvement in research project: 48 monthsEligibility criteriaCriteria for the evaluation of candidates * Candidate’s scientific and professional experience based on his/her participation in conferences, workshops, training courses and internships; participation in research and commercial projects; involvement in scientific societies and associations; international and professional mobility; experience in other sectors, including industry.
Selection processAnnouncement of resultsUp to 30 days after the deadline of documents submission.Additional conditionsA condition of involvement in the project is participation in the Institutes of PAS (after passing the recruitment procedure). Details of the studies are available on Fulfillment of requirements as set out in the Regulations for Granting Scholarships in Research Grants Financed by the National Research Center are available on ( ).Additional commentsAddress to which documents should be submitted:by e-mail to the Secretary for Scientific Purposes: .Please, include the number of the announcement: (10/2024/IGC/PSD) in the title of your e-mail.Additional information is available from:
, * Secretary for Scientific purposes:Application sent after the deadline will not be considered.Once the recruitment process is finished, unsuccessful candidates will be informed about the scores they have obtained at each step of evaluation.Refusal of admission to PDS IPAS takes place by way of an administrative decision. The candidate is entitled to submit a request for reconsideration of the decision to the director of the institute concerned. Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Institute of Human Genetics IPAS Country Poland State/Province wielkopolska voivodeship City Poznań Postal Code 60-479 Street Strzeszyńska 32Contact State/Provincewielkopolska voivodeship CityPoznań WebsiteStreetStrzeszyńska 32 Postal Code60-479 E-Mailphdstudies@igcz.poznan.plSTATUS: EXPIREDShare this page
Poznań, wielkopolskie
Wed, 19 Jun 2024 02:37:56 GMT
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