PhD student-scholarship holder at the Poznan Doctoral School of Institutes PAS, Dept. of Molecular Pathology

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PhD student-scholarship holder at the Poznan Doctoral School of Institutes PAS, Dept. of Molecular Pathology

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Job description

Offer DescriptionThe goal of this project is to develop a novel therapeutic approach for B-cell lymphoma based on targeting the IGH enhancer RNA. To this end, we will conduct a high-throughput screening for small molecules binding to the eRNA transcribed from the essential region in the IGH enhancers. Next, hit compounds will be validated for their effect on lymphoma cell growth and potential toxicity towards normal cells. Finally, selected compounds will be assessed in vivo in mouse xenograft models.Results of our project will indicate novel therapeutic opportunities for treatment of B-cell lymphomas. Our strategy will universally target IGH translocations, regardless of the oncogene involved. This may be especially relevant for the group of so-called double hit B-cell lymphoma patients (with two oncogenes translocated to IGH), who in general respond poorly to current treatment regimens. Results of this pre-clinical proof of concept study will provide novel B-cell lymphoma therapeutics with a direct translation to clinical studies.Keywords:IGH, B-cell lymphoma, enhancer, eRNA, small moleculePredicted tasks in the project:

• active participation in the realization of project goals and analysis of obtained results
• presenting at seminars and conferences, participation in writing scientific papers
• supervision of students

Where to apply E-mail[email protected]RequirementsResearch Field Biological sciences » Biological engineering Education Level Master Degree or equivalentSkills/QualificationsCriteria for the evaluation of candidates * Candidate’s scientific and professional experience based on his/her participation in conferences, workshops, training courses and internships; participation in research and commercial projects; involvement in scientific societies and associations; international and professional mobility; experience in other sectors, including industry.

• Background in molecular biology.
• Candidate’s scientific achievements, based on study grades, scientific and popular science publications, scholarships; prizes and awards resulting from research carried out; student activity or other achievements.
• Communication skills in English.

Requirements for candidates * Background in molecular biology.

• Experience in RNA, cell culture and molecular biology techniques.
• Very good written and oral communication skills in English.
• Motivation and enthusiasm to work in science.
• Good collaborative and team work skill

Specific RequirementsRequired documents * CV, including research achievements.

• Cover letter.
• A copy of the diploma confirming completion of a Master’s Studies Programme, or a certificate of their completion (in the case of diplomas issued by foreign institutions , the diploma referred to in article 326 para.2 point 2 or article 327 para. 2 of the Act of 20 July 2018 – Law on Higher Education and Science (Journal of Laws of 2018, item 1668 as amended), giving the right to apply for a doctoral degree in the country in which the University of Higher Education issuing the diploma operates. If the candidate does not have the above-mentioned documents, s/he is obliged to provide them before being admitted to Poznań Doctoral School IPAS. More information about foreign diplomas is available at:

. * Contact details of at least one current supervisor or other researcher who has previously agreed to issue an opinion about the candidate. The opinion should not be included in the application.

• Consent for the processing of candidate’s personal data for the purposes of the recruitment process
• Application for admission to the Poznań Doctoral School IPAS, together with a consent to the processing of personal data for the purposes of the recruitment procedure plus a statement on his/her familiarity with recruitment regulations for the Poznań Doctoral School (Application is available on:

) * Certificates or other documents indicating level of English language proficiency, if the candidate possesses any.Criteria for the evaluation of candidates * Candidate’s scientific and professional experience based on his/her participation in conferences, workshops, training courses and internships; participation in research and commercial projects; involvement in scientific societies and associations; international and professional mobility; experience in other sectors, including industry.

• Background in molecular biology.
• Candidate’s scientific achievements, based on study grades, scientific and popular science publications, scholarships; prizes and awards resulting from research carried out; student activity or other achievements.
• Communication skills in English.

Languages ENGLISH Level ExcellentResearch Field Biological sciences » Biological engineering Years of Research Experience 1 – 4Internal Application form(s) neededIHG_Application_for_admission.pdfEnglish(151.47 KB – PDF)Additional InformationBenefitsDepartment in which candidate will work: Department of Molecular PathologyDiscipline: Medical SciencePlanned remuneration: scholarship to the value of 4300 PLN gross/per month (3800 PLN net /per month) before the mid-term evaluationPeriod of involvement in research project: 48 monthsEligibility criteriaCriteria for the evaluation of candidates * Candidate’s scientific and professional experience based on his/her participation in conferences, workshops, training courses and internships; participation in research and commercial projects; involvement in scientific societies and associations; international and professional mobility; experience in other sectors, including industry.

• Background in molecular biology.
• Candidate’s scientific achievements, based on study grades, scientific and popular science publications, scholarships; prizes and awards resulting from research carried out; student activity or other achievements.
• Communication skills in English.

Selection processAnnouncement of resultsUp to 30 days after the deadline of documents submission.Additional conditionsA condition of involvement in the project is participation in the Institutes of PAS (after passing the recruitment procedure). Details of the studies are available on Fulfillment of requirements as set out in the Regulations for Granting Scholarships in Research Grants Financed by the National Research Center are available on ( ).Additional commentsAddress to which documents should be submitted:by e-mail to the Secretary for Scientific Purposes: .Please, include the number of the announcement: (10/2024/IGC/PSD) in the title of your e-mail.Additional information is available from:

• Agnieszka Dzikiewicz-Krawczyk:

, * Secretary for Scientific purposes:Application sent after the deadline will not be considered.Once the recruitment process is finished, unsuccessful candidates will be informed about the scores they have obtained at each step of evaluation.Refusal of admission to PDS IPAS takes place by way of an administrative decision. The candidate is entitled to submit a request for reconsideration of the decision to the director of the institute concerned. Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Institute of Human Genetics IPAS Country Poland State/Province wielkopolska voivodeship City Poznań Postal Code 60-479 Street Strzeszyńska 32Contact State/Provincewielkopolska voivodeship CityPoznań WebsiteStreetStrzeszyńska 32 Postal Code60-479 E-Mail[email protected]STATUS: EXPIREDShare this page

Expected salary

Location

Poznań, wielkopolskie

Job date

Wed, 19 Jun 2024 02:37:56 GMT

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