PHD Student no. 14/2024/ICHB/PSD

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PHD Student no. 14/2024/ICHB/PSD

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Job description

Offer DescriptionKEY WORDS: drug design, anticancer drugs, enzyme inhibitors, macromolecular structurePrincipal Investigator: dr hab. Milosz RuszkowskiResearch topic:Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor GrowthI. Project descriptionDo you want to contribute to developing new cancer therapies? We are seeking dedicated scientists to join our project focused on developing SHMT2 enzyme inhibitors to block tumor growth.In our team, you will learn advanced techniques such as high-throughput screening and experimental and computational drug design methods. You will be involved in identifying and optimizing new compounds and performing comprehensive validation through in vitro, in cellulo, and in vivo studies. Your work will be crucial in understanding inhibitor binding mechanisms, enhancing their efficacy, and designing even more effective compounds. Our goal is to create molecules that could revolutionize cancer treatment in the future.Join us to work in a dynamic, supportive environment where your achievements will lead to publications in prestigious journals and contribute to significant breakthroughs in cancer research. Apply today and help us change the future of cancer therapy!Additional information: * Research and doctoral theses shall be carried out within the Sonata-BIS 13 project no. 2023/50/E/NZ7/00501, entitled “
”, funded by the National Science Centre, Poland * PhD students shall receive a stipend in the gross amount of ca 4750 PLN (3790 PLN net), for the period of 48 months with possible extension

• PhD students shall be subject to social insurance, pursuant to article. 6 section 1 passage 7b of the act of October 13th, 1998 on the social insurance system (Journal of Laws of 2019, item 300, 303 and 730).

Where to apply WebsiteRequirementsResearch Field Biological sciences » Biology Education Level Master Degree or equivalentResearch Field Chemistry Education Level Master Degree or equivalentAdditional InformationBenefitsPhD students shall receive a stipend in the gross amount of ca 4750 PLN (3790 PLN net)II. Requirements for the candidates: * Master degree in chemistry, biology, or a related field.

• Experience with laboratory work in the field of the master degree.
• Good command of English, enabling efficient communication and preparation of research papers.
• Ability to make responsible decisions without supervision and adaptability to teamwork.
• Experience in measuring enzyme inhibition, organic synthesis, working with human cell lines, or computational chemistry will be considered as assets but are not a prerequisite.

III. Duties in project: * Protein production.

• Assistance during high-throughput screening.
• Setting up crystallizations and solving complex structures.
• Input during the design of new compounds.
• Measurements of inhibition in vitro.
• Testing efficacy in cellulo.

(Training relevant to the above duties will be provided)IV. Required documents: * Application for admission to PDS IPAS along with the consent for processing personal data upon the recruitment procedure and a statement on having acknowledged the regulations of recruitment for PDS IPAS, using form downloaded from:

• Certified copy of the diploma confirming graduation or a certificate confirming graduation (in the case of diplomas issued by foreign higher education schools, diploma stipulated in article 326, section 2, passage 2 or article 327, passage 2 of the act of July 20th, 2018 – Law on Higher Education and Science (Journal of Laws of 2018, item 1668, as amended), entitling to apply for conferment of a doctoral degree in the state in where such a certificate was issued by the relevant higher education school. In the event when the candidate is not in possession of the aforementioned documents, he/she is obliged to submit them prior to admission to PDS IPAS. Additional information on foreign school diplomas are available at:
• Scientific CV encompassing track record of previous education and employment, information on involvement in scientific activities (participation in student research groups, attendance at scientific conferences, accomplished internships and training, awarded prizes and distinction) and list of publications.
• Cover letter featuring a short description of research interests, achievements and justification for the intention to commence education at the doctoral school.
• Certificates or other documents confirming the degree of proficiency in English, if the candidate is in possession of such materials.
• Contact details of at least one, previous scientific supervisor or another researcher who is entitled to issue an opinion on the candidate.

V. Applications should be submitted via the eRecruiter portal aVI. Submission deadline is July 29, 2024VII. Criteria for evaluation of candidates: * Candidate’s research achievements, pursuant to the grades obtained in the course of studies, scientific publications, awarded scholarships and distinctions resulting from conducting scientific research or student activities or other achievements.

• Candidate’s scientific and professional experience, pursuant to participation in conferences, workshops, training sessions and internships, implementation of research and commercial projects, involvement in scientific trusts and societies, international and professional mobility, experience in other sectors, including industry.
• Candidate’s knowledge on the following discipline: biological sciences.
• Knowledge of the subject matter described in the recruitment advertisement.

Eligibility criteriaVIII. The recruitment procedure shall be concluded no later than August 26, 2024IX. The description of the recruitment process is stipulated in the Regulations of Recruitment for PDS IPAS. Following the recruitment procedure, the unadmitted candidates shall be informed on the number of points obtained at both stages.Incomplete applications will not be considered.For additional information please contact the Principal Investigator:dr hab. Milosz Ruszkowskie-mail:Information clause:Pursuant to the stipulations of the regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), further referred to as GDPR, we hereby inform that:

• The Institute of Bioorganic Chemistry, Polish Academy of Sciences, seated in Noskowskiego St. 12/14, 61-704 Poznan; REGON 000849327, NIP 777-00-02-062 is the administrator of the collected personal data (further referred to as the Institute).
• The Administrator appointed a Data Protection Officer, who can be contacted in writing, via traditional mail, by sending a letter to the following address: Z. Noskowskiego St. 12/14, 61-704 Poznan, or by sending an e-mail to:

. * The personal data of the candidates is processed for the purposes of fulfilling the tasks of the administrator, associated with conducting the recruitment procedure for a vacant position.

• The legal basis for processing personal data is the Act of 26 June 1974 – The Labor Code, Act of 30 April 2010 on the Polish Academy of Sciences or the consent of the person whose data shall be subjected to processing.

Selection process

• Your personal data shall be subjected to processing for a period of 3 months upon the date of the decision of the recruitment committee. Following this period, the data will be irretrievably and effectively destroyed.
• The personal data of the candidates shall not be transferred to any third country.
• The person whose data shall be subjected to processing has the right to:

• request access to his/her personal data, and to amend it or delete it, pursuant to articles 15-17 of GDPR;
• limit data processing, in the events stipulated in article 18 of GDPR;
• data transferring, pursuant to article 20 of GDPR;
• withdraw consent at any moment, without influencing compliance with the law of the processing that was executed prior to consent withdrawal;
• file a complaint to the Inspector General for Personal Data Protection.

Providing personal data in the scope stipulated in article 22 (1) of the Act of 26 June 1974 – The Labor Code is mandatory, whereas providing data in a broader scope is voluntary and requires consent for its processing.Work Location(s)Number of offers available 1 Company/Institute Institute of Bioorganic Chemistry, PAS Country Poland State/Province wielkopolska City Poznań Postal Code 61-704 Street Zygmunta Noskowskiego 12/14 GeofieldContact State/Provincewielkopolska CityPoznan WebsiteStreetNoskowskiego 12/14 Postal Code61-704 E-Mail[email protected]STATUS: EXPIREDShare this page

Expected salary

Location

Poznań, wielkopolskie

Job date

Sat, 29 Jun 2024 22:22:38 GMT

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