PhD student in Biochemistry, Structure and Function of Archaeal Chromatin
Universiteit van Leiden
The project is aimed at understanding structure, function and evolution of archaeal histone proteins. It is embedded in a dynamic multidisciplinary research group (biochemistry, biophysics, molecular microbiology, genetics, microscopy) with long-standing expertise in the structure and function of chromatin in bacteria and archaea. See www.archaealchromatin.com. The group is part of the section Macromolecular Biochemistry at the Leiden Institute of Chemistry, in which a diverse of range macromolecular systems is investigated to understand their structure-function relationships. Moreover, the group is associated with the Centre for Interdisciplinary Genome Research (CIGR) and the Centre for Microbial Cell Biology (CMCB). The candidate is expected to be able to work independently and as a team player in this multidisciplinary environment. The candidate is also expected to have good experimental and, ideally, writing skills. The internationally oriented research group provides a friendly, inclusive and stimulating working environment, with excellent training in hard and soft skills in preparation for careers in academia and industry.The chromosomes of bacteria and archaea are organized and compacted into a nucleoid. This is achieved by the action of nucleoid-associated proteins that fold the genome by bending, wrapping or bridging it. In our group we investigate, using a quantitative approach, the mechanisms employed by the various proteins that are involved in DNA organization and compaction both from a molecular and a cellular perspective (Peeters et al., Nature Rev Microbiol, 2015; Dame et al., Nature Rev Gen, 2020).The goal of this sub-project is to define by using biochemical, biophysical techniques, and structural biology, the role and DNA structuring properties of known and newly identified conventional (Henneman et al., PLOS Gen, 2018; Henneman et al., Nucl Acids Res, 2021) and non-conventional archaeal histone proteins (Ofer et al., Comm Biol, 2023; Hu et al., Nucl Acids Res, 2024; Schwab et al., biorXiv, 2024).The project involves collaboration with Dr Sebastian Geibel and Dr Steffen Brünle.Work and profile
The PhD student will independently perform and analyze experiments. The outcomes of the 4-year project are expected to be written in a PhD thesis, which is to be evaluated by an expert committee, and to be published as journal articles.We are looking for a highly motivated candidate with:
Description of organisation and terms of employment
The chemistry and life science research in the Leiden Institute of Chemistry (LIC) is organized around two major research areas: ‘Chemical Biology’ and ‘Energy & Sustainability’. The institute’s research themes illustrate the central position of chemistry between biology, medicine and physics. The various research topics carried out within these themes are ideal for executing interdisciplinary research.The position is available immediately. We offer a position for 12 months , upon satisfactory performance to be extended for three more years. You will be appointed in accordance with the Collective Labour Agreement for Dutch Universities. The salary ranges from € 2.770,- to € 3.539,- gross per month, depending on experience (pay scale P).
€2770 – 3539 per month
Leiden, Zuid-Holland
Tue, 06 Aug 2024 23:12:44 GMT
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