PhD student: Discovery of novel bioactive metabolites driving tomato-fungi chemical warfare
VIB
About the lab
The group of Specialized Metabolism (https://www.psb.ugent.be/groups/specialized-metabolism [https://www.psb.ugent.be/groups/specialized-metabolism] ), led by Prof. Alain Goossens at the VIB-UGent Center for Plant Systems Biology, is looking to recruit 1 PhD student. The Goossens lab focuses on characterizing plant signaling networks that steer plant-specialized metabolism within tightly regulated fitness programs, particularly those modulated by stress hormones such as jasmonate.
The Department of Plant Systems Biology (PSB) belongs to the Flanders Institute for Biotechnology (VIB) and the Ghent University (UGent), both equal-opportunity employers. PSB is a world-leading plant science institute located at the heart of a renowned Plant Biotech campus in the lovely and lively city of Ghent, Belgium. Its mission is to integrate genetics, genomics and bio-computing to unravel plant biological processes and further translate this knowledge into societal value. Please visit www.psb.ugent.be [http://www.psb.ugent.be] for more information. Job description
Chemical communication via specialized metabolites determines interactions between fungi and plants. Fungi possess a metabolite treasure trove, with potent applications for agriculture and human health, yet the vast majority await discovery, typically because their biosynthesis is silent in lab conditions. Within this PhD project, you will exploit an innovative plant-based platform to discover, study and produce yet unknown fungal metabolites. The plant-based platform is designed based on novel, paradigm-shifting insights acquired during our past research on plant stress hormones. As such, we expect it will offer unprecedented possibilities to activate and study fungal metabolism.
As the PhD student recruited for this project, you will execute cutting-edge research in plant and fungal molecular biology and immunity. Your main aim will be to discover and characterize fungal biosynthetic gene clusters involved in the production of novel bioactive metabolites. This will involve technologies such as transcriptomics, metabolomics, CRISPR/Cas-based gene editing, and synthetic biology, both in plants and fungi.
The research to be performed within this PhD project is framed within a large-scale collaborative venture with the research groups of Prof. Kris Audenaert (https://www.ugent.be/bw/plants-and-crops/en/research/appliedmycologyandphenomics/overview.htm) and Prof. Marjan De Mey (www.csb.ugent.be), both located at the UGent Faculty of Bioscience Engineering.Profile
You have a master’s degree in Biochemistry, Molecular Biology, Bio-engineering, Plant Biotechnology, Microbiology or equivalentYou’re fascinated by plant-fungi interactions, plant immunity, gene discovery, regulation of metabolism, and bioactive metabolites
Gand, Flandre-Orientale
Wed, 09 Oct 2024 22:10:42 GMT
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