Job title:
PhD student Cytokine Signaling in Macrophages
Company:
Job description
Offer DescriptionYou will be investigating cytokine signaling pathways in macrophages, beyond the known JAK-STAT signaling pathways. Cytokines shape the macrophage’s phenotype, thereby affecting disease states. Puzzlingly, many cytokines with opposing functions, utilize highly similar JAK-STAT signaling cascades, leaving it unclear how cytokine-specific responses can occur.The goal is to reveal novel, cytokine-specific factors regulating macrophage cytokine responses.Your main tasks and responsibilities within this project are:
- Identify transcription factors that regulate macrophage cytokine responses using a natural genetic variation screen;
- Validate and functionally test the identified transcription factors by knockdown/knockout strategies on the cytokine responses of macrophages;
- Next to cell culture experiments, you will use and analyze state-of-the-art approaches such as RNA-sequencing and ChIP-sequencing analysis;
- Translate your findings to disease models;
- Align these findings with human disease.
RequirementsSpecific Requirements
- You have a master’s degree in a field related to biomedical sciences, (medical) biology, biochemistry or bioinformatics;
- You have experience in molecular biology, immunology and transcriptional regulation;
- You are willing to learn how to perform transcriptomic and genomic data analysis and bioinformatics;
- You have excellent communication skills in English, both written and oral;
- You are an enthusiastic team player with positive social skills;
- Experience with bioinformatics (e.g. in R) is preferred.
Additional InformationBenefits
- A flying start to your career in scientific research.
- Plenty of room for personal development with a wide range of training & development of academic skills
- Working on large-scale and own research, with motivated colleagues
- A contract for 6 months with the prospect of extension for the duration.
- Salary scale OIO: between € 3.017 and € 3.824 gross per month based on a fulltime work week (depending on qualifications and experience).
- Additional benefits including an 8.3% end-of-year bonus and 8% holiday pay.
. * Your pension is accrued at BeFrank. A modern, understandeble en fair pension
- Excellent accessibility with public transportation and reimbursement of a large portion of your travel expenses. Additionally, we have plenty of parking spaces at the AMC location and a good bicycle scheme.
Additional commentsNote: The first round of interviews is scheduled for Wednesday 5th or Thursday 6th of June 2024. We ask you to take this into account in advance.In addition, applications will be processed continuously during the publication period. If the vacancy is filled, it will be closed prematurely.If you have any questions about this position, please feel free to contact Marten Hoeksema, Group leader of the Medical Biochemistry department, via .For more information about the application procedure, please contact Rhiannon Sandfort, Recruitment advisor, via .A reference check, screening and hiring test may be part of the procedure. Read whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).Internal candidates will be given priority over external candidates in case of equal suitability.Acquisition in response to this vacancy is not appreciated. Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Amsterdam UMC Country Netherlands City Amsterdam Postal Code 1105AZ Street Meibergdreef 9 GeofieldWhere to apply WebsiteContact CityAmsterdam Zuidoost WebsiteStreetMeibergdreef 9 Postal Code1105 AZSTATUS: EXPIRED
Expected salary
Location
Amsterdam, Noord-Holland
Job date
Fri, 03 May 2024 07:10:37 GMT
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