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Company Description
Über AbbVie
AbbVie ist ein globales, forschendes BioPharma-Unternehmen. Unsere Mission ist es, innovative Therapien zu erforschen und bereitzustellen, um die medizinischen Herausforderungen von heute und morgen anzugehen. AbbVie will einen echten Unterschied im Leben der Menschen machen – über verschiedene Therapiegebiete hinweg: Immunologie, Onkologie, Neurologie, Augenheilkunde und Virologie sowie mit dem Portfolio von Allergan Aesthetics in der medizinischen Ästhetik. In Deutschland ist AbbVie an seinem Hauptsitz in Wiesbaden und seinem Forschungs- und Produktionsstandort in Ludwigshafen vertreten. Weitere Informationen findest du unter www.abbvie.de. Folge @abbvie_de auf X oder besuche unsere Profile auf YouTube oder LinkedIn. Unter www.abbvie-care.de findest du umfangreiche Informationen zu den Therapiegebieten, in denen AbbVie tätig ist.
Job Description
This doctoral candidate position is open within the context of the Doctoral Network (DN) project MC4DD (Macrocycles for Drug Discovery) within the framework of the Marie Skłodowska-Curie Actions (MSCA).
This PhD position is hosted at AbbVie Germany GmbH & Co. KG, in 67061 Ludwigshafen, Germany, with 2 secondments for 3 months each at University of Torino (Italy), and at Technical University Darmstadt (Germany).
Responsibilities:
Define a set of macrocyclic model substrates spanning a range of key structural and physicochemical parameters;
Generate in vitro data on permeability and efflux substrate properties using cellular models: Caco2, MDCK (+MDR1 & BCRP efflux transporters)
for a selected subset of compounds, use mouse PK cassette studies to determine in vivo brain/plasma ratio, absolute brain and plasma compound levels, and determine free fraction in brain homogenate to calculate Kp,uu,brain.
Determine the desired property space for brain penetrant macrocycles by analyzing relationships between endpoints determined above, e.g. SAR (relationship between structural or physicochemical properties and in vitro permeability / efflux or in vivo brain penetration), and in vitro – in vivo (relationship between in vitro permeability / efflux and and in vivo brain penetration)
Measurement of chameleonicity of brain-permeable MCs (during 3-months secondment at University of Torino, Italy)
Analysis of Structure-Activity-Relationships (SAR) of brain-permeable MCs (during 3-months secondment at Technical University Darmstadt, Germany)
Qualifications
MSc or equivalent in Biology, Pharmaceutical or Life Sciences
Research experience in biological, biochemical or related fields
Scientific interest, dedication to research, and career goal to work in drug discovery
Appreciation for interdisciplinarity and proactive drive to collaborate across fields
Proficiency in English, good communication skill and social competence
Hands-on experience with in vitro assays, ideally with cell culture systems
Hands-on experience with animal experiments, ideally through participation in a FELASA course, and willingness to perform in vivo studies in mice and/or rats (e.g. dosing, and blood/ tissue sampling)
Ability and willingnes to work independently in an industry environment
Eligibility criteria
Supported researchers must be doctoral candidates, i.e. not already in possession of a doctoral degree at the date of the recruitment.
Mobility Rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in Germany >12 months in the 36 months preceding their recruitment date.
Additional Information
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status. To learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html (US & Puerto Rico only)
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