Job title:
PhD | Preclinical Characterization of New FAPI Radioligands for Metastatic Tumor Targeting
Company:
Job description
Offer DescriptionAccounting for 90% of cancer-related deaths, metastasis represents the greatest challenge in oncology, as cancer cells spread to vital organs and evade traditional therapies such as chemotherapy and external beam radiotherapy. Recent clinical evidence points to targeted radioligand therapy as a breakthrough approach to addressing this gap in cancer care, offering highly effective treatments with minimal side effects. This PhD project centers on the investigation of cutting-edge FAPI radioligands that specifically target the tumor microenvironment, focusing on Fibroblast Activation Protein (FAP), which is overexpressed in the metastatic stroma across a wide range of cancers. This pan-cancer, one-fits-all approach seeks to employ newly developed FAP inhibitor (FAPI) radioligands designed to improve tumor retention and precision in targeting metastatic lesions for therapeutic applications. Through comprehensive in vitro and in vivo studies, the project will assess the pharmacokinetics, tumor targeting, retention, therapeutic efficacy, and radiobiological effects of radiolabeled FAPI analogues in advanced metastatic models, benchmarking their performance against existing agents. By advancing this innovative research, the project aims to deliver more effective, targeted therapeutic options with fewer side effects, creating new opportunities for treating patients with hard-to-treat metastatic cancers.Where to apply WebsiteRequirementsResearch Field Biological sciences » Biology Education Level Master Degree or equivalentResearch Field Medical sciences Education Level Master Degree or equivalentSkills/QualificationsThe minimum diploma level of the candidate needs to be
- Master of sciences
The candidate needs to have a background in
- Biology
- Medical
Specific RequirementsEstimated duration
- 4 years
Expert group
- RadioPharma Research
Languages ENGLISH Level ExcellentAdditional InformationBenefitsWhy would you choose to perform your PhD research at SCK CEN? * Academic & research-oriented: SCK CEN ensures a close cooperation with the academic sector, combined with the unique character of our international research environment. You will work together with supportive experienced experts and use innovative facilities, specifically designed for nuclear experiments.
- Multidisciplinary research: Your PhD is inextricably linked with other areas of expertise, either because of the versatile character of your own topic, or indirectly thanks to knowledge exchanges with colleagues.
- Excellent training centre: SCK CEN is proud of its own SCK CEN Academy, which organises our own internal training courses. Obviously, you can also benefit from these opportunities and the Academy’s excellent reputation.
Eligibility criteriaSelection processAdditional commentsWebsite for additional job detailsWork Location(s)Number of offers available 1 Company/Institute SCK CEN Country Belgium State/Province Antwerp City Mol Postal Code 2400 Street Boeretang GeofieldContact CityMol WebsiteStreetBoeretang 200 Postal Code2400 E-Mail[email protected]STATUS: EXPIREDShare this page
Expected salary
Location
Belgique
Job date
Sat, 11 Jan 2025 04:48:36 GMT
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