PhD Position: Molecular Mechanisms of Protein Biogenesis
Offer DescriptionAre you curious about how cells produce functional proteins? Do you want to push the envelope of applying single-molecule techniques to complex macromolecular systems? Join our single-molecule lab to study co-translational folding and chaperone function.Your job
We are working at the interface of biochemistry, molecular biology and biophysics to follow the journey of nascent proteins toward their functional structures as they emerge from the ribosome. These mechanistic studies pave the way for targeted interventions against protein misfolding and perturbed protein homeostasis which are important for a number of aging-related diseases, including neurodegeneration, and several forms of cancer.The research group of , which just relocated from Johns Hopkins University to Utrecht, has established single-molecule optical tweezers assays for probing nascent protein folding on the ribosome. These studies have shown how the ribosome and molecular chaperones counter misfolding and help large, multi-domain proteins attain their functional structures. The group is now combining mechanical manipulation with single-molecule fluorescence detection. These in vitro studies are complemented by cellular assays. Collectively, the work is revealing fundamental principles of cellular protein biogenesis.As a PhD in our group, you will:
The position is embedded in the research group of Professor Christian Kaiser at the with state-of-the-art facilities, including brand-new molecular biology/biochemistry equipment and single-molecule instrumentation.RequirementsSpecific RequirementsWe are looking for enthusiastic, highly motivated experimentalists who are eager to participate in our research.Ideally, you meet several or all of the following criteria:
Previous experience with single-molecule techniques and/or quantitative biophysical methods is welcome but not required.We foster diversity and encourage applications from female candidates.Additional InformationBenefitsWe offer:
In addition to the laid down in the CAO NU, Utrecht University has a number of schemes and facilities of its own for employees. This includes schemes facilitating , leave schemes and schemes for , as well as discounts on software and other IT products. We also offer access to additional employee benefits through our Terms of Employment Options Model. In this way, we encourage our employees to continue to invest in their growth. For more information, please visit .Selection processAs Utrecht University, we want to be a for everyone. We value staff with diverse backgrounds, perspectives and identities, including cultural, religious or ethnic background, gender, sexual orientation, disability or age. We strive to create a safe and inclusive environment in which everyone can flourish and contribute.If you are enthusiastic about this position, just apply via the ‘apply now’ button! Please enclose:
If this specific opportunity isn’t for you, but you know someone else who may be interested, please forward this vacancy to them.Additional commentsIf you have any questions that you’d like us to answer, please contact at .Do you have a question about the application procedure? Please send an email to . Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Universiteit Utrecht Country Netherlands City Utrecht Postal Code 3584CH Street Padualaan 8 GeofieldWhere to apply WebsiteContact CityUtrecht WebsiteStreetDomplein 29 Postal Code3512 JESTATUS: EXPIRED
€2770 – 3539 per month
Utrecht
Sun, 05 May 2024 05:01:41 GMT
To help us track our recruitment effort, please indicate in your email/cover letter where (vacanciesineu.com) you saw this job posting.
Job title: Postdoctoral researcher Ice-interactive biomaterials Company: Eindhoven University of Technology Job description Job descriptionJoin…
Job title: Employé commercial frais libre-service H/F Company: Système U Job description Votre mission principale…
Job title: Electrical project manager Company: LeasingTeam Job description LeasingTeam Professional wspiera polskie i globalne…
Location: Salisbury (SP2) - Wiltshire, South West, United Kingdom Salary: £28k - 29k per year…
Job title: Product Owner - Software Modernization Company: Telenet Job description Job Description:Jouw verantwoordelijkheden :…
Job title: LISS DTP Partnership Coordinator Company: King's College London Job description Job descriptionLondon Interdisciplinary…