PhD Position: Molecular Mechanisms of Motor Neuron Degeneration

Job title:

PhD Position: Molecular Mechanisms of Motor Neuron Degeneration

Company:

Radboud University

Job description

Job description Do you hold a Master’s degree in Neuroscience, Molecular Biology/Neurobiology, Biomedical Sciences, Biochemistry, Genetics, or a related field, or are you close to obtaining such a degree? Are you a critical and creative thinker and passionate about science? Are you interested in exploring the molecular mechanisms underlying motor neurodegenerative disease and performing cutting-edge biomedical research? If so, you have a part to play as a PhD candidate!We are recruiting a PhD candidate who will work independently on mouse genetics projects. Your main project will involve investigating the role of the skeletal muscle in ALS associated with mutations in TDP-43. You will use mouse genetic and viral gene transfer approaches, and evaluate the disease course of model mice using motor behavioural analysis and electromyography (EMG). Furthermore, neuropathological analysis will involve immunohistochemistry, fluorescent in situ hybridisation (FISH), and confocal and super-resolution imaging. You will use state-of-the-art in vivo non-canonical amino acid tagging (NCAT) to evaluate protein synthesis, as well as molecular biology, biochemistry, and next-generation sequencing, including single-nuclei sequencing. In addition, you will have the opportunity to contribute to other ongoing projects in the lab, for example studying the molecular pathogenesis of CMT peripheral neuropathy associated with mutations in tRNA synthetases, following up on our published work (e.g. Zuko, Mallik et al, Science, 2021). You will have the opportunity to collaborate with a senior postdoctoral researcher who will provide practical/experimental guidance. You will get some exposure to teaching in Master’s courses, and you will have the opportunity to collaborate with and supervise Bachelor and Master’s students.Requirements

• You are a highly motivated, passionate, critical, and creative individual who wants to grow as a scientist.
• You are team-oriented, open to provide and receive feedback, and keen to engage in scientific discussions.
• You either hold a Master’s degree in Neuroscience, Molecular Biology/Neurobiology, Biomedical Sciences, Biochemistry, Genetics, or a related field, or are close to obtaining one.
• Previous experience with mouse genetics and molecular biology is a plus.
• You have permission to work with mice (Article 9 – FELASA B).
• We are a dynamic international lab, so a good command of English is essential.

Conditions of employment

• We will give you a temporary employment contract (1.0 FTE) of 1.5 years, after which your performance will be evaluated. If the evaluation is positive, your contract will be extended by 2.5 years (4-year contract).
• You will receive a starting salary of €2,901 gross per month based on a 38-hour working week, which will increase to €3,707 from the fourth year onwards (

). * You will receive an 8% holiday allowance and an 8,3% end-of-year bonus.

• You will be able to use our

. The Dual Career Programme assists your partner via support, tools, and resources to improve their chances of independently finding employment in the Netherlands. Our Family Support Service helps you and your partner feel welcome and at home by providing customised assistance in navigating local facilities, schools, and amenities. Also take a look at our page to discover all our services for international employees. * You will receive extra days off. With full-time employment, you can choose between
of annual leave instead of the statutory 20.
Work and science require good employment practices. This is reflected in Radboud University’s primary and secondary . You can make arrangements for the best possible work-life balance with flexible working hours, various leave arrangements and working from home. You are also able to compose part of your employment conditions yourself, for example, exchange income for extra leave days and receive a reimbursement for your sports subscription. And of course, we offer a good pension plan. You are given plenty of room and responsibility to develop your talents and realise your ambitions. Therefore, we provide various training and development schemes.

Department The Storkebaum lab combines Drosophila and mouse genetics to unravel molecular mechanisms underlying motor neurodegenerative and neuromuscular disorders. Our current focus is on Charcot-Marie-Tooth (CMT) peripheral neuropathy associated with mutations in tRNA synthetases and on amyotrophic lateral sclerosis (ALS) associated with mutations in FUS and TDP-43. More broadly, we are interested in the molecular mechanisms underlying axonal degeneration, with a focus on the role of mRNA translation defects. We use a broad spectrum of methods and techniques including a recently developed method for cell-type-specific in vivo labelling of newly synthesised proteins (NCAT), several high-end imaging techniques (confocal and super-resolution microscopy), single-molecule FISH, single-cell/single-nucleus transcriptomics, whole genome sequencing, mouse and Drosophila behavioural analysis, electromyography, histology, immunohistochemistry, molecular biology and biochemistry.Our dynamic and international team currently consists of three postdoctoral researchers, four PhD candidates and two technical assistants. In addition, we have strong local, national and international collaborations with scientists working on RNA biology and genetics. You will have the opportunity to attend and present your work to various audiences in lab meetings, several institute seminars, and to attend national and international conferences. We attracted substantial external funding, including an ERC consolidator grant, two JPND grants, two Muscular Dystrophy Association (MDA) grants, two grants from the Dutch ALS Association, and grants from the Radala Foundation for ALS Research, AFM, ARSLA, Prinses Beatrix Spierfonds, and the Dutch Research Council (NWO). We have several recent papers in high-impact journals, including Science (2), Nature Neuroscience (3), Journal of Cell Biology, Nature Communications (5), Acta Neuropathologica (2), and EMBO Journal.Additional information You can apply only via the button below. Address your letter of application to Prof. Erik Storkebaum. In the application form, you will find which documents you need to include with your application.The first interviews will take place on Wednesday 26 February. Any second interview will take place on Wednesday 12 March. You will preferably start your employment on 1 April 2025.We can imagine you’re curious about our . It describes what you can expect during the application procedure and how we handle your personal data and internal and external candidates.

Expected salary

€2901 per month

Location

Nijmegen, Gelderland

Job date

Thu, 16 Jan 2025 23:05:19 GMT

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