PhD position in Radiopharmaceutical Sciences

Job title:

PhD position in Radiopharmaceutical Sciences

Company:

Job description

Offer Descriptionradionuclide therapy is that radioactivity doses are delivered in the tumor very accurately. During this treatment, a radiopharmaceutical is administered to the cancer patient. This radiopharmaceutical is combining a radionuclide and a tumor-targeting vector, that selectively binds to a target protein aberrantly upregulated at the surface of the cancer cells. Emissions of beta and/or alpha particles by the radionuclide cause lethal damage to tumor cells. Prior to the treatment, a diagnostic scan is made to assess the localization of the tumor lesions, as well as proper staging and stratification of the patients that can undergo radionuclide therapy. Currently, the diagnostic imaging drug is chemically different from the therapeutic, which can lead to inadequate treatment. Differences between these diagnostic and therapeutic drugs are eliminated by developing theranostic twins. Molecular twins are chemically identical, and therefore they have identical in vivo behavior and can serve for both imaging and therapy. In fact, the molecular twins contain the diagnostic and the therapeutic nuclide, and depending on the application one nuclide is radioactive, whereas the other one is still present but under its non-radioactive form. This innovative approach is based on easily available fluorine-18 for PET-diagnostics combined with b- or a-emitters for therapy. With these twins the right cancer patients are selected for treatment with optimal therapy. In this project funded by NWO-TTW, UMCG and Erasmus MC will develop theranostic twins for treating cancer. The best twin will be prepared for a first-in-man clinical trial.Where to apply WebsiteRequirementsSpecific RequirementsApplications are invited from enthusiastic and talented young researchers with an active interest in tracer development and translational radiopharmaceutical research. Qualifications and skills:

• You have a Master’s degree in organic chemistry, (radio)pharmaceutical chemistry or similar.
• You have already experience in organic chemistry or medicine chemistry.
• You are at ease operating analytical and preparative HPLC systems.
• You have excellent command of English, both spoken and written.
• You have a positive, interactive and agile mindset, and enjoy continuously expanding your experimental and therotical competences.

These criteria are considered advantages, but not requirements:

• Previous experience in handling radioactivity and performing radiolabeling procedures.
• Practical experience with cell culture and in vitro assays.
• Theoretical knowledge of pharmacology and tumor biology.

Additional InformationBenefits

• You will receive a temporary position for 4 years.
• The gross monthly salary is € 3.017,- in the 1st year and increases to € 3.824,- in the 4th year (scale OIO).
• excellent fringe benefits, such as a 13th month that is already paid out in November and an individual travel expense package.
• An International Office which aids you in preparing for you arrival and stay.
• Pension insurance with ABP, we take care of 70% of the monthly contribution.
• Special benefits, such as an in-company physiotherapist and bicycle repairer. There is also a gym where you can work on your fitness after work.

Selection processFor more information about this position, please contact Dr. Yann Seimbille, .If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.Additional commentsFor more information about this position, please contact Dr. Yann Seimbille, .If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website. Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Erasmus MC Country Netherlands City Rotterdam Postal Code 3015 GD Street Dr. Molewaterplein 40Contact CityRotterdam WebsiteStreetDr. Molewaterplein 40 Postal Code3015 GDSTATUS: EXPIREDShare this page

Expected salary

€3017 per month

Location

Rotterdam, Zuid-Holland

Job date

Fri, 06 Sep 2024 22:45:37 GMT

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