PhD fellowship in Single-Cell Proteomics at NNF-CPR, ICMM and Novo Nordisk
Københavns Universitet
We invite applications for a PhD Fellowship in Single Cell Proteomics commencing 1 September 2024 or as soon as possible thereafter. The position will be based at the NNF Center for Protein Research (CPR) and Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen and close collaboration with the Omics Technologies Department , Translational Research at Novo Nordisk A/S. Information about CPR can be found at:Our research
The successful candidate will join the Olsen Group at the Center for Protein Research led by Professor Jesper Velgaard Olsen. We specialize in quantitative, high-resolution mass spectrometry-based proteomics. Our primary focus includes advancing mass spectrometric technology and exploring biological applications, with a particular emphasis on addressing crucial questions in biology and biomedicine. Our goal is to contribute significantly to understanding signaling networks and their impact on cellular responses, particularly in human disease models and in primary human tissues.The Department of Cellular and Molecular Medicine (ICMM) offers an ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programmes, three high profile Research Centers as well as a number of international research groups. The scientists at ICMM are involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen. You can read more atThe project is part of an exciting research collaboration project between Novo Nordisk a/s, Copenhagen University Hospital Hvidovre and University of Copenhagen using state-of-the-art single-cell sequencing technologies for deep molecular profiling of paired samples in healthy patients and patients with obesity, T2D, and/or MASLD. The overall aims of the collaborative project are to provide new disease insights, identification of novel drug targets and biomarker discovery.Project descriptionThe PhD project in single-cell proteomics aims to develop a high-throughput and high-sensitivity method for LC-MS/MS-based spatial-proteomics on FFPE samples from liver and adipose tissue (WAT/SAT) and single cells proteomics (SCP) on peripheral blood mononuclear cells (PBMCs) from patient samples collected as part of the CELLFI cohort. In addition, we aim to develop methods for SCP analyses on fresh liver and adipose tissue using relevant pre-clinical animal models that translates well to human sample.The selected candidate will spearhead the development of proteomics sample preparation protocols for high-throughput single-cell proteomics analysis by high-resolution mass spectrometry and their application to patient liver samples, adipose tissue and PBMCs from the CELLFI cohort.In addition to the main project tasks, the role provides avenues for the successful applicant to contribute to other ongoing projects within the Olsen group.Principal supervisor: Professor Jesper Velgaard Olsen, NNF Center for Protein Research, University of Copenhagen. E-mail:Co-advisors: Principal Scientist Mads Grønborg, Omics Technologies Department, Translational Research, Novo Nordisk A/S, Professor Lise Lotte Gluud, Gastro Unit, Copenhagen University Hospital HvidovreStart: 1 September 2024Duration: 3 years as a PhD fellowJob description
Your key tasks as a PhD fellow at SUND are:
Essential qualifications and skills
Desirable experience and skills
Place of employmentThe place of work is at the Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen. We offer supportive, creative, and stimulating working conditions within a dynamic and international research environment. Our proteomics research facilities include a LEAF Bronze certified lab with state-of-the-art LC-MS equipment.
All qualified applicants will receive full consideration. Candidates who, through their research, teaching, and/or service, contribute to diversity and competencies of our Institute are encouraged to apply.The University of Copenhagen strives to offer a family friendly and flexible working environment with a sustainable balance between work- and private life, including parental leave schemes (up to 47 weeks for both parents) and up to six weeks of paid holidays per year. Researchers that have not been tax liable in Denmark for the last 10 years can apply for a special (reduced) tax scheme. The university offers a variety of services for international researchers and accompanying families.Terms of employment København
Wed, 12 Jun 2024 06:06:29 GMT
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