PhD fellowship in organoid modelling of the post-acute phase of COVID at the Department of Biomedical Sciences
Københavns Universitet
Faculty of Health and Medical SciencesUniversity of CopenhagenWe are offering a PhD fellowship in organoid development and tissue modelling commencing 1st of October 2024 or as soon as possible hereafter.Our group and research
The Desler Group are a newly started research group counting 10 group members. We investigate aging at the molecular level and its link to age-related diseases. This is done using 2D and advanced 3D cell culture models alongside biopsies collected from human cohorts. Our goal is to unveil novel molecular mechanisms in aging, discover robust biomarkers for age-related diseases, and identify potential therapeutic targets.This PhD project is part of an EU Horizon funded highly interdisciplinary and multifaceted research project between 10 different groups across Europe and lead by the Desler Group.Project descriptionIn this project we aim to understand and explain the mechanistic link between the post-acute phase (PAP) of COVID-19 and risk of noncommunicable diseases. More specifically, we aim to determine the clinical and biological mechanisms behind the increased risk of reduced organ function in pulmonary, cardiovascular, and renal systems associated with the PAP of COVID-19.Your primary research area will be to generate, assess and use induced pluripotent stem cell (iPSC)-derived organoids to support the project. You will optimize the protocols for kidney and lung organoid generation and use this model system to assess novel immune factors in blood samples from human controls and patients suffering from COVID. Using both 2D and 3D representative model systems, you will, in collaboration with other group members assess viability, fibrosis, senescence load, bioenergetic changes and morphologic changes.Principal supervisor is Associate Professor Claus Desler, Department of Biomedical Sciences, cdesler@sund.ku.dkStart: 1st of October 2024Duration: 3 years as a PhD studentJob description
We are seeking a highly motivated and ambitious candidate with a strong educational background in human organoid development biology. The perfect candidate has experience with generation, assessment and use of induced pluripotent stem cell (iPSC)-derived organoids.As a PhD candidate in the Desler group, you will take on both teaching- and research-related responsibilities, including the supervision of students associated with this project.We strive for great outreach in our project, and part of the job includes presenting and communicating our research to the public as well as to the scientific community.Your key tasks as a PhD fellow at SUND are:
Key criteria for the assessment of applicants
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project, e.g. Cell biology, Human Biology, Molecular Biology, Biochemistry and similar. Please note that your master’s degree must be equivalent to a Danish master’s degree (two years).Other important criteria are:
Place of employmentThe place of employment is at the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment.Terms of employment
The average weekly working hours are 37 hours per week.The position is a fixed-term position limited to a period of 3 years. The start date is 1st of October or as soon thereafterThe employment is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.
København
Sat, 15 Jun 2024 01:08:39 GMT
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