PhD fellowship in In Vivo Pharmacology at the Section for Preclinical Disease Biology Department of Veterinary and Animal Sciences
KU – SUND – IVS
Faculty of Health and Medical SciencesUniversity of CopenhagenWe are offering a PhD fellowship in In Vivo Pharmacology commencing from October 1st 2024 or as soon as possible thereafter.Our group and research
The Experimental Pharmacology and Toxicology Lab – The ExPT Lab – are experts in designing and conducting preclinical studies of drugs and toxins. We host the graduate program for In Vivo Pharmacology and Experimental Animals. Our major in house projects focus on metabolic fatty liver disease, effects of vitamin C deficiency, and drug-induced liver injury. Our group consists of people with a range of different scientific backgrounds covering e.g. veterinary medicine, analytical chemistry, molecular biology. Our vision is that ‘Our research and the students and scientists we train have a high international level and contribute globally to evidence-based disease prevention and treatment’. Within this group you will be part of a dedicated and highly experienced team of scientists with many successful PhD projects behind them.Project descriptionThe present project is a collaboration between the Experimental Pharmacology and Toxicology Lab and the Laboratory of liquid crystalline nano-self-assemblies (Pharmaceutical Physical and Analytical Chemistry group, the Department of Pharmacy) at University of Copenhagen. Metabolic dysfunction-associated steatotic liver disease (MASLD; previously termed: Non-alcoholic fatty liver disease (NAFLD)) is a prominent contributor to morbidity and mortality worldwide. It represents the most common cause of liver disease and life-threatening liver failure due to steatohepatitis (MASH) and associated liver fibrosis, with substantial health-care costs for its prevention or management. In line with the urgent global need for new therapies to treat patients with late-stage liver fibrosis, this collaborative project studies a simple-by-design multifunctional nanotherapeutic platform for treatment. This project will use omega-3 polyunsaturated fatty acids (ω-3 PUFAs) as a viable MASLD/MASH treatment option in combination with adiponectin-derived synthetic short peptides that promote inactivation of hepatic stellate cells (HSCs); the cellular drivers of hepatic fibrosis. The project aims at engineering and characterizing a peptide-coated structurally tunable library of multifunctional cubosomal/hexosomal nanocarriers containing ω-3 PUFAs for accelerated MASLD treatment. The PhD student will interact with the supervisors and a postdoctoral fellow also attached to the project. The primary responsibility of the PhD student will be to design and conduct ex vivo and in vivo studies under supervision to investigate the pharmacokinetics of the constructed nano drugs. Through this integrated in vitro-in vivo profiling, optimized nanosystems will be selected by the group for therapeutic efficacy experiments. This interdisciplinary project integrates innovative aspects of nanoparticle engineering with attributes for production of much needed liver specific drugs targeting liver fibrosis and considers the urgent societal need for introducing effective and low-cost medicines for MASLD treatment.Principal supervisor is Professor Jens Lykkesfeldt, , 35333163.Start: October 1st 2024 or as soon as possibleDuration: 3 years as a PhD studentJob description
Your key tasks as a PhD student at SUND are:
Key criteria for the assessment of applicants
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project, e.g. veterinary medicine or molecular biomedicine. Please note that your master’s degree must be equivalent to a Danish master’s degree (two years).Essential experience and skills:
Desirable experience and skills:
Place of employmentThe place of employment is at the Section of Preclinical Disease Biology, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories and state of the art techniques required for the proposed project.
Terms of employment København
Wed, 19 Jun 2024 22:34:13 GMT
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