mRNA/LNP Process Development Scientist in Monza, Italy

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Office, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)

Job Description

Thermo Fisher Scientific Inc. is the world leader in serving science, with an annual revenue of more than $40 billion. Whether our customers are accelerating life sciences research, solving sophisticated analytical challenges, growing efficiency in their laboratories, improving patient health through diagnostics, or developing and manufacturing life-changing therapies, we are here to support them. Our distributed team delivers an outstanding combination of innovative technologies, purchasing convenience, and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD. We value a diverse range of backgrounds.

We are excited to announce an opportunity within the mRNA Business unit in Monza, Italy! Join the mRNA team in Monza and contribute to helping customers address challenges for patients’ treatment.

Your Future Team

The Scientist joining the team will work within the mRNA Process & Analytical Method Development Group and chip in to the development of process and analytical methods, improvements, and transfer of mRNA products to cGMP and QC groups. The RNA Process and Analytical Development team is a brilliant and upbeat team of Scientists passionate about RNA and LNP technologies.

Responsibilities

• Participate in multi-disciplinary matrix teams on sophisticated projects and lead problem-solving and lessons-learned activities.

• Design and implement experimental plans, analyze in-process data and write and review high-quality reports.

• Develop strong customer relationships through technical interactions.

• Lead activities in the area of mRNA /LNP expertise.

• Provide solutions to identify process risks, issues, and problems.

• Contribute to improving departmental processes and implementing innovative technologies.

• Demonstrate flexibility to support activities within the department.

Qualifications

A Master’s Degree in life science, Chemical, Biological, or Process Engineering, or equivalent experience, with 5+ years of confirmed experience in the Biopharmaceutical industry, preferably in a PD role. Alternatively, a PhD in Biochemistry, Chemistry, Chemical Engineering, Biological Engineering, or related scientific subject areas, or equivalent experience, with +2 years of relevant post-doctoral or industrial experience.

Key Requirements

• Experience with biomolecule purification techniques such as HPLC/FPLC chromatography (including affinity, ion exchange, hydrophobic interactions, and size exclusion), tangential flow filtration (TFF), and other filtration techniques.

• Knowledge of technology transfer and GMP manufacturing.

• Implementation of DoE studies & high-throughput screening for purification processes.

• Understanding in vitro transcription (IVT) critical process parameters, reaction optimization, and scale-up.

• Experience in manufacturing large mRNA molecules, including self-amplifying and circular RNAs.

• Understanding the mRNA-LNP encapsulation process scale-up and execution of relevant associated analytical methods.

• Proven track record of efficiently working in a fast-paced and multifaceted environment.

Thermo Fisher Scientific is an Equal Opportunity Employer.

Join us!

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.