Laboratory Research Scientist – Organ Morphodynamics lab

Job title:

Laboratory Research Scientist – Organ Morphodynamics lab

Company:

Francis Crick Institute

Job description

Laboratory Research Scientist – Organ Morphodynamics labReports to: Rashmi Priya, Group LeaderThis is a full-time, fixed term (12 months) position on Crick terms and conditions of employment.SummaryThis position is for a fixed-term Laboratory Research Scientist (LRS) in the Organ Morphodynamics Laboratory led by Dr Rashmi Priya. The LRS will mainly contribute towards developing novel tools and technologies for the lab and will also run their independent project(s). The suitable candidate will be expected to collaborate with other members of the laboratory and support their ongoing projects. The specific details and aims of the project(s) will be developed in consultation with the supervisor and will also be driven by the candidate’s training and interest.The Research GroupThe heart is the first organ to form and function during embryonic development. A critical step during vertebrate heart development is trabeculation, during which the myocardial wall transforms from a monolayer to a complex structure consisting of two distinct cell types: outer compact layer and inner trabecular layer cardiomyocytes (Priya et al., 2022, Nature; Andrews et al., bioRxiv 2024.07.24.604962). How this topological complexity is achieved is unknown, as are the underlying mechanisms that shape these crucial anatomical structures. In our lab, we aim to unravel the underlying mechanical, molecular and geometric interactions that transform a developing heart from a simple epithelium into a highly intricate patterned organ. We are a highly interdisciplinary and collaborative laboratory. We combine the excellent tractability of zebrafish embryos with quantitative imaging, transcriptomics, biophysics, genetics, and predictive theoretical modelling to answer fundamental questions driving organ morphogenesis.The RoleThe role of a Laboratory Research Scientist in the Crick is diverse and rewarding with numerous training and development opportunities.Key responsibilitiesThese include but are not limited to:

• Contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and lead their own project(s).

• Developing and establishing new tools and techniques which includes generation and validation of zebrafish transgenic lines, HCR techniques, antibody characterisation.
• Providing experimental or technical support to other lab members.
• Contribution to proof-of-concept studies at the initial stages of different projects – which includes generation and validation of various tools (transgenic lines, mutants), imaging and image analysis.
• Willingness to actively contribute to a productive and positive lab atmosphere

Key experience and competenciesThe post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:Essential

• Higher education degree in Biological Sciences, Cell Biology or Developmental Biology (BSc, MSc)
• Practical laboratory experience
• Experience in microscopy imaging and image analysis

• Excellent molecular biology skills

• Excellent oral and written communication skills
• Strong skills in organising and thorough record-keeping
• Strong collaborative ability and teamwork experience
• Strong interest in pursuing independent research

Desirable

• Experience in zebrafish embryological techniques and zebrafish gene editing techniques
• Advanced imaging techniques such as confocal microscopy

Find out what benefits the Crick has to offer:For more information on our great pay and benefits package please click here:Equality, Diversity & Inclusion:We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.Read more on our website:

Expected salary

Location

London

Job date

Sat, 07 Sep 2024 22:04:11 GMT

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