Head of Pharmacokinetics and Pharmacodynamics -M/F/D

Job title:

Head of Pharmacokinetics and Pharmacodynamics -M/F/D

Company:

Pierre Fabre

Job description

Who we are ?Pierre Fabre is the 2nd largest dermo-cosmetics laboratory in the world, the 2nd largest private French pharmaceutical group and the market leader in France for products sold over the counter in pharmacies.Its portfolio includes several medical franchises and international brands including Pierre Fabre Oncologie, Pierre Fabre Dermatologie, Eau Thermale Avène, Klorane, Ducray, René Furterer, A-Derma, Naturactive, Pierre Fabre Oral Care.Established in the Occitanie region since its creation, and manufacturing over 95% of its products in France, the Group employs some 10,000 people worldwide. Its products are distributed in about 130 countries. 86% of the Pierre Fabre Group is held by the Pierre Fabre Foundation, a government-recognized public-interest foundation, while a smaller share is owned by its employees via an employee stock ownership plan.In 2019, Ecocert Environment assessed the Group’s corporate social and environmental responsibility approach in accordance with the ISO 26000 sustainable development standard and awarded it the “Excellence” level.Pierre Fabre is recognized as one of the “World’s Best Employers 2021” by Forbes. Our group is ranked in the Top 3 in the cosmetics industry and in the Top 10 in the pharmaceutical industry worldwide.Your missionWe are looking for a Pharmacokinetics/Pharmacodynamics Group Leader to lead a team of 6 professionals, including PKPD project leaders, Modeling and Simulation experts, and Clinical Pharmacology specialists.The team is responsible for early DMPK and PK/PD studies of both small and large molecules, as well as clinical pharmacology across all phases of clinical development.In this role, you will guide the group in strategy and functional expertise, establish a cohesive PBPK-based modeling approach, mentor your team, and oversee their training and development. You will also work closely with internal experts in data science, oncology, rare diseases, toxicology, and biomarkers to ensure a unified project strategy.Key Responsibilities:Lead, coach, and develop a team of experts in pharmacokinetics, pharmacodynamics, and clinical pharmacology.Provide expert guidance in developing comprehensive DMPK, PK/PD, and regulatory strategies from target validation through post-registration stages.Collaborate with internal stakeholders, including specialists in data science, oncology, rare diseases, toxicology, and biomarkers, to ensure alignment and coherence in project strategies.Oversee the group’s activities and ensure the continuous professional growth and development of your team.Foster a culture of generosity, focusing on supporting and enabling the success of others, creating an environment where your team feels motivated to contribute their best.

​Pierre Fabre recrute en CDI un Responsable du Département pharmacocinétique / pharmacodynamique pour manager une équipe de 6 chefs de projet PKPD, experts en modélisation et simulation et spécialistes en pharmacologie clinique.L’équipe est responsable des premières études DMPK et PK/PD de petites et grosses molécules, ainsi que de la pharmacologie clinique à toutes les phases de développement. Dans ce rôle, vous construirez la stratégie, établirez une approche cohérente de modélisation basée sur le PBPK, encadrerez votre équipe et superviserez leur formation et leur développement. Vous travaillerez également en étroite collaboration avec des experts internes en Data Science, en oncologie, en maladies rares, en toxicologie et en biomarqueurs afin de garantir une stratégie de projet unifiée.Who you are ?Required Qualifications:

• At least 10 years of experience in scientific research within the pharmaceutical industry, specifically in areas related to PK/PD/ADME science.

• Expertise in modeling and simulation approaches.

• Strong experience in either early-stage small molecule discovery or Clinical Pharmacology.

• Experience in leveraging ADME and PK/PD science to address efficacy and safety questions related to human exposure, and influence project strategies, advise on therapeutic dosing design and candidate selection, guide drug discovery strategy, and implement adequate de-risking plans.

• Demonstrated leadership skills, with experience managing teams and individuals.

• Strong expertise in regulatory submissions to health authorities.

Preferred Qualifications:

• Experience in the fields of oncology and/or rare diseases.

• Advanced skills in data analysis and biomarker development.

Une expérience de 10 ans min dans la recherche scientifique au sein de l’industrie pharmaceutique, en particulier en pharmacocinétique, pharmacodynamique et ADME.– Expertise en modélisation et simulation.– Solide expérience dans les approches pour petites molécules phase précoce ou en clinique.– Expérience de l’utilisation des sciences ADME et PK/PD pour répondre aux questions d’efficacité et de sécurité chez l’homme.– Solide expertise en matière de soumissions réglementaires aux autorités de santé.We are convinced that diversity is a source of fulfillment, social balance and complementarity for our employees, which is why our offers are open to all, without restriction.

Expected salary

Location

Langlade, Gard – Toulouse

Job date

Wed, 06 Nov 2024 08:28:04 GMT

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