Chercheur-se post-doc en biologie animale (M/F)

Job title:

Chercheur-se post-doc en biologie animale (M/F)

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Job description

Offer DescriptionThe aim of the postdoctoral project is to determine the impact of missense genetic variants identified in the NR2F1 gene, a key regulator of brain development, on the heterogeneity of neurodevelopmental abnormalities described in patients with the disease. The post-doc will seek to understand how rare genetic mutations in NR2F1 affect cortical development and circuit assembly in ‘humanised’ mouse models. The project will compare the pathological contribution of representative human mutations in different mouse models to understand their phenotypic heterogeneity and unveil pathophysiological mechanisms common to multiple neurodevelopmental diseases. The research project will use histological, molecular, and cellular analyses combined with 3D imaging and scRNAseq transcriptomics.– Participate with the research assistant in the organization of transgenic mouse colonies by genotyping
– Assist with intraperitoneal injections and perfusions of adult animals
– Participate in the collection and dissection of post-natal and adult brains
– Undertake thin sections of brains using a cryostat
– Implement and adapt the various immunohistochemistry techniques required to analyze brain structures
– Monitor cell migration using the in utero electroporation technique
– Use animal biology analysis and experimentation equipment
– Use specific imaging software (Image J, AxioVision, etc) and statistical software (GraphPad)
– Analysing and communicating data (drafting laboratory notebooks, presenting results at follow-up meetings)
– Be familiar with the literature
– Possibly supervise a Masters student
– Write a research article in English
– Ensure that health and safety principles and rules are applied.The team is located in the heart of Nice and is part of the Institute of Biology Valrose (27 teams; 300 members; 25 nationalities; 11 common facilities), an international research center that brings together high-profile teams with complementary areas of expertise and with a common interest in translating basic research into knowledge for the clinic. The iBV provides state-of-the-art core facilities, with a collaborative and lively atmosphere in a gorgeous city/region. For more information, visit .Where to apply WebsiteRequirementsResearch Field Neurosciences Education Level PhD or equivalentResearch Field Biological sciences Education Level PhD or equivalentLanguages FRENCH Level BasicResearch Field Neurosciences Years of Research Experience NoneResearch Field Biological sciences Years of Research Experience NoneAdditional InformationEligibility criteria– PhD with training in neuroscience/neurobiology or developmental biology
– Excellent knowledge of the anatomy and neurogenesis processes of the mouse brain at different ages
– Expertise in mouse genetics, cellular and molecular biology, and microscopy
– Extensive experience in animal experimentation (handling mice, intraperitoneal and subcutaneous injections), dissection, perfusion, and in utero electroporation
– Knowledge of imaging, histology (staining, microscopy) and FACS
– Proficiency in Word, Excel, PowerPoint, Graphpad, and image analysis software (ImageJ, Photoshop, etc).
– Organisational skills, planning, creativity and conscientiousness
– Motivation, perseverance, autonomy and thoroughness
– Able to work independently, but able to adapt and work as part of a team
– Oral and written communication in English (French is not compulsory);
– Authorisation for animal experimentation is desirable.

Additional commentsApplications should contain a CV, a letter of motivation with a description of the research accomplishments (2 pages max), and the contact information of two references can recommend their research work directly to . Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Institut de Biologie Valrose Country France City NICE GeofieldContact CityNICE WebsiteSTATUS: EXPIREDShare this page

Expected salary

Location

Nice, Alpes-Maritimes

Job date

Sun, 21 Jul 2024 23:52:26 GMT

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