Assistant Professor (non tenure track) for investigation of Z-DNA in bacterial biofilms
Aarhus Universitet
Applications are invited for a non tenure track assistant professor position for a period of 20 months in the research group of Professor Rikke Louise Meyer.The position is available from 1 March 2025 or as soon as possible thereafter.Job description/research project/research areaThe position is funded by a recently awarded grant from the Villum Foundation entitled “Z-DNA: The alter ego of DNA in the extracellular space.”
New research shows that eDNA in biofilms is comprised of the canonical right-handed B-DNA helix as well as the left-handed Z-DNA. Z-DNA is interesting because it is stronger, resistant to enzymatic degradation, and is not sticky like B-DNA. In this interdisciplinary project, we will bring knowledge and methods from DNA chemistry and biophysics into microbiology to address how bacteria twist DNA and control the transition between the B and Z forms in the extracellular space.
If we understand how bacteria toggle eDNA between the B and Z forms, we can manipulate its structure to our advantage, e.g. to design resilient Z-DNA-rich biofilms for industrial applications, or to weaken biofilms for fouling control by switching from Z to B.
The scope for using this knowledge also reaches beyond microbiology, as DNA has many applications in biotechnology, and eDNA is implicated in many human disease states.Your profileYou should hold a PhD in molecular biology, microbiology, nanoscience, chemistry, or similar, and have a passion for interdisciplinary research. You have several years of research experience as a postdoctoral researcher and have a proven track record of publishing in high-impact peer-reviewed journals. You have experience with supervision of students and leading your own research project(s).You will be growing bacterial biofilms and visualize matrix components by confocal laser scanning microscopy and super-resolution microscopy. You will collaborate with research groups from chemistry and nanoscience, and you will use a suite of biophysical techniques to characterize biofilms and matrix components. You will also establish new experimental models to study DNA superstructures consisting of genomic DNA in a cell-free environment.The Interdisciplinary Nanoscience Center and the research groupThe place of work is iNANO, the Interdisciplinary Nanoscience Center (www.inano.au.dk), which was established in 2002 and at present is a major research and education center based at Aarhus University hosting 60 senior scientists, ~100 Postdocs and ~100 PhD students.
The center combines expertise and faculty from Physics, Chemistry, Molecular biology and Medicine to carry out world class interdisciplinary research in Nanoscience and Nanotechnology.
The center gives access to a broad range of infrastructure, tools and expertise including clean-room facilities. With a 5 year undergraduate nanotechnology program and nanoscience graduate program (www.inanoschool.au.dk) the center provides a full educational environment. In addition to the large base of basic research, the center has a large number of ongoing industrial projects and partnerships.works on interdisciplinary projects centered around bacterial biofilms: How they form and gain tolerance to antibiotics, and how they can be prevented or treated in industrial or clinical settings.Place of work and area of employmentThe place of work is Gustav Wieds Vej 14, 8000 Aarhus C and the area of employment is Aarhus University with related departments.Contact informationFor further information, please contact Professor Rikke Louise Meyer
Phone: +4560202794
E-mail:Application procedureShortlisting is used. This means that after the deadline for applications – and with the assistance from the assessment committee chairman, and the assessment committee if necessary, – the head of department selects the candidates to be evaluated. The selection is made on the basis of an assessment of who of the candidates are most relevant considering the requirements of the advertisement. All applicants will be notified within 6 weeks whether or not their applications have been sent to an expert assessment committee for evaluation. The selected applicants will be informed about the composition of the committee and will receive his/her assessment. Once the recruitment process is completed a final letter of rejection is sent to the deselected applicants.
Aarhus, Midtjylland
Wed, 23 Oct 2024 22:09:00 GMT
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