Assistant Professor 186.2024 – Dioscuri

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Assistant Professor 186.2024 – Dioscuri

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Job description

Offer DescriptionJob offer no. 1227.1101.186.2024RECTOR of the Jagiellonian Universityannouncesa selection procedure for the position ofan ASSISTANT PROFESSORProject Title: “Dioscuri Centre for Modelling of Posttranslational Modifications”Field of science: Natural sciencesDiscipline: Biological SciencesScope: Molecular and structural biology, biotechnologyNumber of posts: 1Type of employment: Fixed-term employment contractWorking time: Full- timePlanned duration of employment: 3 yearsExpected date of employment commencement: The third quarter of 2024Project description:We are currently seeking applications for a 3-year Postdoctoral position to explore the interactions between glycoproteins and the extracellular matrix (ECM) components. The ECM is a multifaceted web of proteins and carbohydrates that constitutes the structural underpinning of biological tissues. ECM interacts with membrane proteins and affects how they diffuse in cellular membranes. Glycans, the carbohydrate moieties that decorate majority of membrane proteins, are generally expected to shield intermolecular interactions. Therefore, glycosylation status is expected to alter how membrane proteins move in ECM and affect their physiological functions. These effects are expected to be profound in cases where lateral clustering defines protein function, e.g. in immune cells or neuronal synapses. Preliminary results from our experimental collaborators have indicated that the lateral mobility of neurotransmitter receptors in neuronal membranes is affected by ECM, and varies depending on receptor glycosylation status (i.e., differs among distinct glycoforms), with potential profound functional consequences. Interestingly, glycan types are frequently altered in conditions ranging from neurological diseases to congenital disorders of glycosylation, but the role of glycans in modulating receptor dynamics and function remain poorly understood.In this Project, together with experimental and computational partners we plan to address this gap.Objectives:ECM models: Using results from super-resolution microscopy as well as mesoscopic simulations performed by our collaborators, develop and validate atomistic and coarse-grained (Martini) model of fragments of neuronal ECM.Glycoprotein diffusion: By performing large-scale molecular dynamics simulations, investigate how glycans influence the diffusion properties of neurotransmitters within the ECM.Experimental-Computational Synergy: Work closely with glyconeurobiology experts to cross-validate our computational findings with single-protein tracking experiments.Disease Relevance and Translation: Uncover how altered glycanprotein and glycan-glycan interactions contribute to neurological diseases. Our work aims to shed light on the glycan-dependent mechanics of neurotransmitter receptors and synaptic transmission, offering routes for novel therapeutic strategies.Through this project, we wish to offer insights into the role glycans play in protein-ECM interactions in neurons and cells in general, thereby creating a ripple effect across neurobiology, pharmacology, and medical research.The successful candidate will be a part of the Dioscuri Centre for Modelling of Posttranslational Modifications, which is an integral part of the Dioscuri Program, a Max Planck Society initiative, co-funded by the German and Polish Ministries of Science.The Malopolska Centre of Biotechnology JU and the Dioscuri Centre strive to ensure a workplace with equal opportunities. We celebrate diversity and are committed to creating an inclusive environment for all members irrespective of gender, nationality or disabilities.Where to apply E-mail[email protected]RequirementsResearch Field Biological sciences » Other Education Level PhD or equivalentSkills/QualificationsThe selection procedure is open for all individuals, who meet the requirements set out in Articles 113 and 116.2.3) of the Act of 20 July 2018 – Law on Higher Education and Science, and who meet the following eligibility criteria according to § 165 of the Statute of the Jagiellonian University:

• holding at least a doctoral degree;
• having relevant scientific achievements;
• taking active part in scientific life.

Specific RequirementsAdditional requirements and expectations:

• PhD degree in biophysics, computational biology, chemistry, bioinformatics, or a related field,
• experience in performing molecular dynamics simulations / Monte Carlo simulations / docking simulations, as well as experience in constructing models of large biomolecular complexes,
• familiarity with Unix and programming experience (python, bash) are essential,
• knowledge of cell biology and experience in large-scale simulations are welcome,
• excellent communication skills and fluency in English.

Languages ENGLISH Level ExcellentAdditional InformationBenefitsWe offer:

• stable employment based on an employment contract at a renowned university,
• cooperation with the interdisciplinary academic community represented by established experts in the field,
• scientific support as well as the possibility of qualification improvement and professional development,
• access to research infrastructure,
• competitive salary,
• close interactions with the dept. of Theoretical Biophysics at the Max Planck Institute of Biophysics in Frankfurt am Main led by Gerhard Hummer, partner of the Dioscuri Centre,
• benefits in the form of sports activities – multisport card, medical packages, group insurance,
• opportunity to enjoy additional social benefits.

Selection processRequired application documents:

• resume,
• personal questionnaire filled in by the candidate,
• copy of the Doctoral diploma and, if applicable, of the candidate’s Habilitation diploma,
• information on the candidate’s scientific, teaching and organizational achievements,
• declaration of the candidate, confirming that the Jagiellonian University will be their primary place of work, should they be selected in the selection procedure,
• statement under Article 113 of the Law on higher education and science,
• statement on acknowledging and accepting the rules and regulations concerning intellectual property management and commercialization in force at the Jagiellonian University,

Declaration forms (no. 5-7) and personal questionnaire template (no. 2) can be obtained at:Additional application documents:

• list of publications (along with respective publishers and page numbers), electronic versions for non-open access publications

The course of selection procedure:The first stage of the selection procedure is the formal assessment of the submitted documents. Applications which meet all formal requirements are the subject of substantive assessment, during which an interview with the Candidate may be conducted (directly or via electronic communication channels), upon settling the date of the interview with the Candidate. The Candidate has the right to appeal against the negative assessment by the selection board within 7 days from receiving the information about the results of the assessment.The selection procedure is conducted in accordance with The Policy of Open, Transparent and Merit-Based Recruitment Process.Additional commentsForm of submission:by e-mail to the address: , title: “Assistant Professor (Post-doc) – Dioscuri”Deadline for submission of applications: 19.07.2024Expected date of the selection procedure settlement: 09.08.2024Method of communicating of the results of the selection procedure: by e-mailQuestions: For further information please contact dr. Mateusz Sikora, e-mail address: ,In the selection procedure, the Jagiellonian University follows the principles of the European Charter for Researchers and a Code of Conduct for the Recruitment of Researchers.Jagiellonian University does not provide housing.Work Location(s)Number of offers available 1 Company/Institute Malopolska Centre of Biotechnology JU Country Poland GeofieldContact State/ProvinceMalopolska CityCracow WebsiteStreetGronostajowa 7a Postal Code30-387STATUS: EXPIREDShare this page

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Location

Kraków, małopolskie

Job date

Thu, 20 Jun 2024 00:13:21 GMT

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