Job title:
Assistant Professor
Company:
Job description
Offer DescriptionAn estimated 850 million people worldwide is affected by chronic kidney disease (CKD). Patients with CKD have a 10 to 30 times increase in cardiovascular diseases (CVD) risk compared to subjects with normal renal function, which cannot be attributed solely to traditional cardiovascular risk factors. Urea is quantitatively the most abundant retained solute in the body, where it is in equilibrium with its reactive decomposition product, cyanate, that can react with lysine residues and N-terminal amino groups of proteins and peptides, resulting in the formation of homocitrulline. This modification occurs at multiple sites within a single protein, altering protein charge, structure, and function.Based on our results we hypothesise that circulating, urea-derived cyanate leads to carbamylation-triggered alterations of RAS/KKS system components, including the major player in the blood pressure regulation; angiotensin converting enzyme I (ACE1). Therefore, we will investigate impact of carbamylation on critical elements of RAS/KKS system, including ACE1, bradykinin and chymase. We will also evaluate the role of carbamylation on ability of endothelium to exert its physiological functions and the use of recombinant bacterial enzyme to reverse the carbamylation process..Scope of duties: according to the Annex 1 to the Work Regulations of the Jagiellonian University – Model scopes of responsibilities and duties of academic teachers.Where to apply E-mail[email protected]RequirementsResearch Field Biological sciences » Other Education Level PhD or equivalentSkills/QualificationsThe selection procedure is open for all individuals, who meet the requirements set out in Articles 113 and 116.2.3) of the Act of 20 July 2018 – Law on Higher Education and Science, and who meet the following eligibility criteria according to § 165 of the Statute of the Jagiellonian University:
- holding at least a doctoral degree;
- having relevant scientific achievements;
taking active part in scientific lifeSpecific Requirements
- Confirmed experience in the field of molecular biology (particularly skills in the field of genetic engineering, including the generation of stable transgenic strains and methods of expressing recombinant proteins in bacterial and eukaryotic systems)
- Experience in animal models (small rodents) is an additional advantage.
- International research experience.
- Publications with first authorship in journals from the ISI list.
- Advanced knowledge of English (spoken and written).
- Ability to prepare presentations and scientific texts.
Languages ENGLISH Level ExcellentResearch Field Biological sciences » OtherAdditional InformationBenefits
- stable employment based on an employment contract at the renowned university,
- cooperation with the interdisciplinary academic community represented by well-known scientists,
- scientific support as well as the possibility of qualifications improvement and professional development,
- access to research infrastructure,
- benefits in the form of a Multisport card, sports activities, medical packages, group insurance,
additional social benefits.Eligibility criteriaRequired application documents: * CV
- personal questionnaire for the applicant for employment,
- copy of the doctoral or postdoctoral diploma,
- information on the candidate’s scientific, teaching and organisational achievements,
- declaration of the candidate, confirming that the Jagiellonian University will be their primary place of work, should they be selected in the selection procedure,
- statement under Article 113 of the Law on higher education and science,
- statement on acknowledging and accepting the rules and regulations concerning intellectual property management and commercialisation in force at the Jagiellonian University.
Declaration forms (no. 5-7) and personal questionnaire template (no. 2) can be obtained at:Additional documents: * list of publications (including publisher and number of citations),
- review of the doctoral thesis or dissertation – if the Candidate has one,
- opinion on the Candidate’s predisposition and qualifications for scientific work,
statement of compliance with the competition requirements, with a detailed description of how each requirement was met.Selection processThe first stage of the selection procedure is the formal assessment of the submitted documents. Applications which meet all formal requirements are the subject of substantive assessment, during which an interview with the Candidate may be conducted (directly or via electronic communication channels), upon settling the date of the interview with the Candidate. The Candidate has the right to appeal against the negative assessment by the selection board within 7 days from receiving the information about the results of the assessment.Additional commentsForm of submission: by e-mail to the address:title: ADIUNKT_OPUS_24_MYDELFor further information please contact by e-mail:Work Location(s)Number of offers available 1 Company/Institute Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology Country Poland State/Province Malopolska City Kraków Postal Code 30-387 Street 7 Gronostajowa Str GeofieldContact State/ProvinceMalopolska CityKrakow WebsiteStreet7 Gronostajowa Str. Postal Code30-387 E-Mail[email protected] Phone+48126646110STATUS: EXPIREDShare this page
Expected salary
Location
Kraków, małopolskie
Job date
Sat, 21 Sep 2024 07:45:35 GMT
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