Job title:
Postdoctoral position in bioinformatics/evolutionary genomics (M/F)
Company:
Job description
Offer DescriptionWe offer an 18-month postdoctoral position in bioinformatics/evolutionary genomics to study the genetic basis of sex determination and resistance to vertical transmission of Wolbachia endosymbionts encoded by sex chromosomes in the isopod Armadillidium nasatum.
To this end, the work will consist in analyzing genomic sequence datasets available in our laboratory (nanopore, HiC, poolseq…), including de novo assembling, gene annotation, mapping, SNP and structural variant analyses, etc.Performing bioinformatics analyses of high throughput sequencing data
Reporting results of experiments
Writing scientific articles
Making oral communications at national and international meetingsThis position is funded by ANR project Resist, led by Richard Cordaux. One of the goals of the project is to elucidate the genetic basis and evolutionary consequences of sex determination perturbations induced by Wolbachia endosymbionts in isopod crustaceans. Vertically transmitted through the maternal line, Wolbachia increases its transmission by converting genetic males into phenotypic females in many isopods (Cordaux et al. 2011; Cordaux & Gilbert 2017). This leads to sex ratio biases in favor of females, which causes genetic conflicts favoring the evolution of resistance genes allowing the restoration of balanced sex ratios. We have shown that such a resistance system exists in the isopod Armadillidium nasatum, which blocks Wolbachia vertical transmission (hence restoring males in progenies) and whose genetic basis is associated to sex chromosomes (of the XY/XX type in this species) (Becking et al. 2019).
The hired person will work in collaboration with two scientists (Richard Cordaux and Clément Gilbert) and will benefit from a scientific environment comprising numerous bioinformaticians. More generally, the hired person will have many opportunities to interact with other scientists of the EGCE laboratory and the IDEEV institute. Finally, the hosting group has the dedicated bioinformatics equipment.
Preferred starting date: March 2025 (negotiable)
References
Becking T et al. 2019. Sex chromosomes control vertical transmission of feminizing Wolbachia symbionts in an isopod. PLOS Biology. 17:e3000438. doi: 10.1371/journal.pbio.3000438.
Cordaux R, Bouchon D, Greve P. 2011. The impact of endosymbionts on the evolution of host sex-determination mechanisms. Trends Genet. 27:332-41.
Cordaux R, Gilbert C. 2017. Evolutionary Significance of Wolbachia-to-Animal Horizontal Gene Transfer: Female Sex Determination and the f Element in the Isopod Armadillidium vulgare. Genes. 8:186. doi: 10.3390/genes8070186.Where to apply WebsiteRequirementsResearch Field Biological sciences Education Level PhD or equivalentResearch Field Environmental science Education Level PhD or equivalentLanguages FRENCH Level BasicResearch Field Biological sciences Years of Research Experience NoneResearch Field Environmental science Years of Research Experience NoneAdditional InformationEligibility criteriaPhD in bioinformatics, evolutionary genomics or a related domain; knowledge in programming (Python, R…) and the UNIX/LINUX environment; strong experience in manipulation and analyses of sequence datasets from the latest sequencing technologies. Knowledge in molecular evolution would be appreciated. The hired person must demonstrate rigor and autonomy in the organization of their mission and be able to work in a team.Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Évolution, génomes, comportement et écologie Country France City GIF SUR YVETTE GeofieldContact CityGIF SUR YVETTE WebsiteSTATUS: EXPIREDShare this page
Expected salary
Location
Gif-sur-Yvette, Essonne
Job date
Sat, 04 Jan 2025 03:10:05 GMT
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