Associate Director, Translational Medicine Assay Strategist, Immuno-Oncology

Job title:

Associate Director, Translational Medicine Assay Strategist, Immuno-Oncology

Company:

AstraZeneca

Job description

We are recruiting an Associate Director, Translational Medicine Assay Strategist, Immuno-Oncology, AstraZeneca Oncology R&D.Location: BarcelonaDo you feel passionate about the possibilities of outstanding science changing lives of cancer patients? Do you have a background in oncology and/or translational research and an interest in working with Cell Therapies or immune bispecifics as part of an exciting portfolio? If so, this may be the role for you. We currently have an exciting opportunity for a highly motivated Associate Director to join our translational medicine team supporting our exciting internal Cell Therapy programs.About AstraZenecaAstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. Within AstraZeneca Oncology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death.The Translational Medicine function exists within AstraZeneca R&D to ensure effective and strategic biomarker studies for Oncology project teams. Closely interacting with the pre-clinical Discovery, Early Clinical Development, and Precision Medicine & Biosamples diagnostics functions, the Translational Medicine team is the single point of accountability for delivery of robust, scientifically-driven biomarkers to all project teams, providing feasibility assessments, technical validation, centralized biomarker analysis capability for clinical samples, delivery of translational science research and early clinical phase engagement.What you’ll do/Job descriptionWe are seeking an Associate Director in Oncology Translational Medicine to manage and deploy clinical trial assays, ensuring delivery of high quality translational data within our internal Cell Therapy oncology project portfolio teams. The role will work in partnership with the Translational Medicine team and Translational Medicine Leads, to implement flow cytometry, cytokine analysis RNAseq, and other translational assays to gain understanding of pharmacodynamic, mechanism of action, and patient stratification biomarkers.ResponsibilitiesDelivering translational assay readiness for pre-clinical therapies through Ph 2 clinical studies based on the best available science and technologies.Generating assays and delivering data on disease linkage to guide indication selection and support patient selection hypotheses.Support clinical implementation of assays for target engagement, pharmacodynamic, and mechanism of action biomarkers.Key assays types are Flow Cytometry, IHC, transcriptomics, soluble proteins, and ctDNADelver data to reliably and quantifiably inform clinical decisions for selecting therapeutically relevant doses and schedules.Surveying and c­­ommunicating current landscape of translational assays in academic and industry settings.Understanding key cancer pathway interactions, feedback mechanisms, and features of tumor microenvironment in clinical samples to guide rational dr­­­ug combinations.Defining novel mechanisms of resistance to targeted therapies by studying tumors at relapse and methods to assess them.Influencing translational strategy across the AZ portfolio.Collaborating across Translational Medicine and Clinical teams to facilitate appropriate incorporation of Translational Medicine strategies for molecules in early phases of development in Oncology.Collaborating with clinical operations and clinical teams to define sample collection, lab manuals and clinical study protocols, and biomarker analyses in clinical studies related to oncology.Contributing to and ensuring the quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications and recommendations to development teams and management for GNG decisions.Leading internal and external research collaborations in areas of clinical technologies and oncology translational research.Essential for the rolePhD and/or MD with experience in drug development.A minimum of 5 years’ of relevant experienceExperience in clinical trials and clinical operationsIn-depth knowledge of immunology, oncology, and translational science.Broad experience in human clinical trial immune assays such as flow cytometry, IHC, RNAseq, multiplex cytokines, and functional studiesAbility to drive, manage, execute and deliver results for complex multi-functional projects.Highly developed problem solving and risk management skills, and attention to detail.Highly developed collaborative working skills.Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca.Proven ability to motivate and develop others.Desirable for the roleExpertise in Cell Therapy; T cell engaging bispecifics, or other immuno-oncologyProject management experience desiredWhy AstraZeneca?At AstraZeneca we’re dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare. Naturally curious, we are forever connecting and collaborating. Uncovering new insights that equip us to challenge convention and push the boundaries. We are a global, science-led biopharmaceutical company and our innovative medicines are used by millions of patients worldwide.Committed to living our values – they guide our behaviours, actions and decisions, everyday. With our ground-breaking pipeline comes a bright future – exciting opportunities and varied work. We’re on an exciting journey to pioneer the future of healthcare.Date Posted 23-jul-2024Closing Date 16-ago-2024AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Expected salary

Location

Barcelona

Job date

Thu, 25 Jul 2024 07:20:29 GMT

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